PURPOSE To evaluate carcinogenic human papillomavirus (HPV) mRNA for E6 and E7 mRNA detection on clinical specimens to identify women with cervical precancer and cancer. EXPERIMENTAL DESIGN We evaluated a prototype assay that collectively detects oncogenes E6/E7 mRNA for 14 carcinogenic HPV genotypes on a sample of liquid cytology specimens (n=531), masked to clinical data and to the presence...

Bioassays for carcinogenicity of various primary processing products (crude oils or tars) and commercial products obtained from Estorian oil shale have been carried out since 1951. The products (undiluted or diluted) were painted twice weekly 50 times on the interscapular area of the skin of random-bred or CC57Br mice. The products processed at high temperatures have a higher carcinogenic activ...

During the course of a study of the effect of the oral administration of certain polycydic hydrocarbons on the growth of the rat,7 a paper by Haddow, Scott, and Scott2 appeared which reported that growth retardation had been produced in the rat by a single intraperitoneal injection of certain carcinogenic hydrocarbons. These authors further observed that similar injections of non-carcinogenic c...

1. Unsubstituted 6-membered aromatic ring systems (fused, unfused, or mixed) chrysene mutagenic initiator carcinogenic pyrene co-carcinogen mutagenic benzo[a]pyrene mutagenic carcinogenic fetotoxic teratogenic benzo[e]pyrene carcinogenic mutagenic benzo[a]anthracene mutagenic carcinogenic benzo[c]phenanthrene initiator mutagenic naphthalene inhibitor phenanthrene initiator mutagenic anthracene ...

The pollution of water bodies with heavy metals can result into the possible contamination freshwater fish. levels Pb, Fe, Cu, Zn, Ni and Cd were investigated in fish samples (Ameiurus nebulosus, Pylidictis olivaris, Tilapia zilli, Clarias gariepinus) collected from Kwanar-Are dam located at Rimi local government area Katsina State, Nigeria health risks evaluated estimated. mean concentration r...

I. Patulin 409 A. Introduction 409 B. Toxicity 410 C. Cellular Effects 412 D. Biosynthesis and Biochemical Effects 413 II. Penicillic Acid 414 A. Introduction 414 B. Chemical Properties 415 C. Analysis 416 D. Biochemistry 417 E. Biological Properties 417 F. Natural Occurrence 420 II I. Other Carcinogenic Lactones 420 A. Lactones as Alkylating Agents 420 B. Five-Membered Carcinogenic Lactones 42...

BACKGROUND The distribution of HPV genotypes, their association with rigorously confirmed cervical precancer endpoints, and factors associated with HPV infection have not been previously documented among HIV-infected women in India. We conducted an observational study to expand this evidence base in this population at high risk of cervical cancer. METHODS HIV-infected women (N = 278) in Pune,...

The binding of labeled carcinogens [3H]benzo(a)pyrene [3H]dibenz(a,/i)anthracene, and [3H]dibenz(a,c)anthracene to nuclear chromatin was examined in AKR mouse embryo cells grown in culture. The influence of unlabeled weakly and strongly carcinogenic polycyclic aromatic hydrocar bons (PAH) and the metabolic inhibitor 7,8-benzoflavone on the binding of labeled PAH to nuclear chromatin was examine...