Cerebral venous outflow was measured in anesthetized dogs at the confluence of the sagittal and straight sinuses, with the lateral sinuses occluded. Denervation of the carotid bifurcation increased systemic arterial pressure (+ 25.8; SE ±7.7 mm Hg) and decreased cerebral vascular conductance (—0.018; SE ± 0.005 ml/min•un Hg); stimulation of the carotid sinus nerve decreased systemic arterial pr...

Cerebral venous outflow was measured in anesthetized dogs at the confluence of the sagittal and straight sinuses, with the lateral sinuses occluded. Denervation of the carotid bifurcation increased systemic arterial pressure (+ 25.8; SE ±7.7 mm Hg) and decreased cerebral vascular conductance (—0.018; SE ± 0.005 ml/min•un Hg); stimulation of the carotid sinus nerve decreased systemic arterial pr...

BACKGROUND There is recent interest in the role of carotid bifurcation anatomy, geometry and hemodynamic factors in the pathogenesis of carotid artery atherosclerosis. Certain anatomical and geometric configurations at the carotid bifurcation have been linked to disturbed flow. It has been proposed that vascular dimensions are selected to minimize energy required to maintain blood flow, and tha...

Although cellular adhesion molecules (CAMs) are hypothesized to play an important role in atherogenesis, the relationship between CAMs and systemic atherosclerosis is uncertain. Among 92 outpatients (48 men; mean+/-SD age, 65+/-9 years), we evaluated the association of soluble vascular CAM-1 (sVCAM-1) and intercellular adhesion molecule-1 (sICAM-1) with carotid intimal-medial thickness (IMT), a...

Twenty-two cervical carotid artery bifurcations were evaluated in 11 patients using a high-resolution computed tomographic (CT) technique with image reformation permitting display of the bifurcation anatomy. Arteriography was also done in eight of the patients, two of whom subsequently underwent carotid endarterectomy. The CT study showed patency of the proximal internal carotid artery in every...

BACKGROUND the purpose of this study was to analyze the in vivo distribution of absolute wall shear stress (WSS(abs)) and oscillatory shear index (OSI) in the carotid bifurcation and to evaluate its dependence on bifurcation geometry, the presence of internal carotid artery (ICA) stenosis, and recanalization therapy. METHODS AND RESULTS time-resolved 3D blood flow was acquired with flow-sensi...

BACKGROUND Human anatomy texts in current use have very little precise information as to the frequency of variations in the bifurcation of the common carotid artery, and a clear description of the relation between external and internal carotid arteries as well as the variation of the origin of the ascending pharyngeal and superior thyroid arteries is limited. MATERIAL AND METHODS Sixty common...

BACKGROUND AND PURPOSE An increase in intima-media thickness (IMT) in the common carotid artery (CCA) is commonly used as a marker of atherosclerosis. The purpose of this study was to investigate the relationship between IMT in the CCA and atherosclerosis in the carotid bifurcation. METHODS 182 consecutive patients (mean age, 67 years) referred for carotid duplex scanning were included. We me...

Copyright © 1983 American Heart Association. All rights reserved. Print ISSN: 0009-7330. Online ISSN: TX 72514 Circulation Research is published by the American Heart Association. 7272 Greenville Avenue, Dallas, 1983;53;502-514 Circ. Res. CK Zarins, DP Giddens, BK Bharadvaj, VS Sottiurai, RF Mabon and S Glagov with flow velocity profiles and wall shear stress Carotid bifurcation atherosclerosis...

An unusual case of peripheral hypoglossal nerve palsy, caused by lateral position of the external carotid artery and an abnormally high carotid bifurcation is reported. Improvement followed ligation and cutting of the external carotid artery at its origin.