We have previously shown (Sunkara et al., 1989; Taylor et al., 1991) that 6-o-butanoyl castanospermine (BuCast) was a 30-50-fold better inhibitor of HIV syncytia formation than castanospermine (Cast). Radiolabeled Cast and BuCast were used to study the uptake and metabolism of these compounds in cultured cells and in mice. BuCast was preferentially taken up by cells compared to Cast. Approximat...

OBJECTIVE A limited number of clinical trials have shown that the total contact cast (TCC) is an effective treatment in neuropathic, noninfected, and nonischemic foot ulcers. In this prospective data collection study, we assessed outcome and complications of TCC treatment in neuropathic patients with and without peripheral arterial disease (PAD) or (superficial) infection. RESEARCH DESIGN AND...

The aim of this study was to analyze the efficiency of the mandibular banded and cast splint anchorage forms used in Herbst treatment. The records of 16 Class II:1 subjects treated with mandibular banded premolar anchorage (group A), 19 Class II:1 subjects treated with mandibular banded premolar-molar anchorage (group B), 34 Class II:1 subjects (group C), and 18 Class 11:2 subjects treated with...

Introduction: Hip spica casting is an important component of treatment for developmental dysplasia of the hip (DDH) and popular treatment method for femur fractures in children. Breakage at the hip region is a relatively common problem of this cast. We have developed a three-slab technique of hip spica application using fibreglass as the cast material. The purpose of this review was to evaluate...

BACKGROUND Serial casting is an effective treatment modality in early-onset idiopathic scoliosis; however, the role of this method in congenital scoliosis is not well studied. METHODS A total of 11 patients with progressive congenital scoliosis were treated with serial cast application. Age at initial cast application, magnitudes of the congenital, compensatory and sagittal deformities, coron...

OBJECTIVES Pediatric forearm torus fracture, a frequent reason for emergency department visits, can be immobilized by both rigid cast and nonrigid methods. However, controversy still exists regarding the optimal treatment of the disease. The aim of this study was to compare, in a systematic review, clinical efficacy of rigid cast with nonrigid methods for immobilization of the pediatric forearm...

Background: Distal radius fracture is common in the general population. Fracture management includes a plaster cast, splint and synthetic material cast to immobilise the injured arm. Casting complications are common in those conventional casting technologies. 3D printing technology is a rapidly increasing application in rehabilitation. However, there is no clinical study investigating the appli...

Heat treatments are frequently used to modify the microstructure and mechanical properties of materials according requirements their applications. Laser surface treatment (LST) has become a relevant technique due high control parameters localization involved in modification. It allows for rapid transformation near surface, resulting minimal distortion workpiece bulk. LST encompasses, turn, lase...

The segregation of the elements during solidification and the direct formation of destructive phases such as Laves from the liquid, result in in-homogeneity of the cast structure and degradation of mechanical properties. Homogenization heat treatment is one of the ways to eliminate destructive Laves from the cast structure of superalloys such as 718Plus. The collected data presents the effect o...