To evaluate whether serum Cathepsin S (Cat S) could serve as a biomarker for the diagnosis and prognosis of gastric cancer (GC), Enzyme-linked immuno sorbent assay (ELISA) was used to detect serum Cat S in 496 participants including healthy controls and patients with benign gastric diseases, gastric cancer, esophageal cancer, liver cancer, colorectal cancer, nasopharyngeal cancer and lung cance...

The CC chemokine, eotaxin1 (CCL11) is an important regulator of eosinophil function. A marked accumulation of eosinophils in tissues has been correlated with the up-regulation of eotaxin1 expression in several diseases. The potential therapeutic value of neutralizing the effects of eotaxin1 in inflammatory conditions (including asthma) is under investigation. A human single-chain fragment varia...

Several lysosomal cathepsins have been implicated in a number of diseases, from arthritis to cancer. A recent member of the cathepsin family, cathepsin S (Cat S) has been associated with several types of cancer in humans. However, to date, no report has linked Cat S to human hepatocellular carcinoma (HCC). Here, we investigated the expression of Cat S in human normal and HCC livers using immuno...

BACKGROUND The pathophysiological changes of COPD tend to worsen with progression, triggering limiting symptoms and implying the decrease in the activities of daily living and quality of life. The COPD Assessment Test (CAT) is a questionnaire designed to measure the impact of COPD on the health status. The aim of this study was to evaluate the impact of the disease through the CAT in a Brazilia...

This study analyzed the association between risk factors and Feline panleukopenia at Ichiyo Veterinary Clinic, Madiun using a retrospective method. A total of 2037 data used was secondary obtained from cat medical ambulatory reports January 2018-March 2021. The included age, gender, vaccination status, comorbid diseases, housing system, number cats, season. Data presented descriptively Chi-Squa...

BACKGROUND Cathepsin S (Cat S) is overexpressed in human atherosclerotic and aneurysmal tissues and may contributes to degradation of extracellular matrix, especially elastin, in inflammatory diseases. We aimed to define the role of Cat S in cardiac inflammation and fibrosis induced by angiotensin II (Ang II) in mice. METHODS AND RESULTS Cat S-knockout (Cat S(-/-)) and littermate wild-type (W...

reports indicate that one of the causes of harmful to the genital system, especially the testes is stress. result of damage to testicular quality certainly will affect the quality of sperm fertility. stress could be created secondarily after some pathological conditions such as neurological diseases or environmental factors. one of the causes of stress could be scary voices, such as cat voice f...

reports indicate that one of the causes of harmful to the genital system, especially the testes stress. stress could be created secondarily after some pathological conditions such as neurological diseases or environmental factors. one of the causes of stress could be scary voices, such as cat voice for mice. in this study we aimed to investigate the testes parameters in the animals that were ex...

cataract is multi-factorial eye disease identified by the disturbance of the transparent ocular lens. there is significant evidence suggesting oxidative damage as a major cause of initiation and progression of numerous diseases including cataracts. nad(p)h:quinone oxidoreductase 1 (nqo1; omim: 125860) and catalase (cat, omim: 115500) are antioxidant enzymes that prevent cells from oxidative str...