The sequence of cytochrome P4501A (CYP1A) cDNA of medaka (Oryzias latipes) was determined, and its messenger ribonucleic acid (mRNA) regulation by beta-naphthoflavone (betaNF) was evaluated. The determined cDNA sequence contained 2,349 base pairs (bp), and the open reading frame contained a total of 1,563 bp encoding 521 predicted amino acids. The induction of CYP1A mRNA in medaka was evaluated...

I have read with interest the case report “Bilateral multicystic renal dysplasia with Potter sequence. A case with penile agenesis” by Dursun et al.1 The authors stated that the case “provides most symptoms of bilateral multicystic hereditary renal adysplasia (HRA)”. Although most cases of renal adysplasia (agenesis/ dysplasia) are sporadic, some cases are inherited. Hereditary renal adysplasia...

The Journal recently published an article by Galipeau et al. (1) about loss of heterozygosity (LOH) at chromosomes 9p and 17p and clonal heterogeneity in Barrett’s esophagus. The article described a high prevalence of LOH at 9p and 17p in endoscopic biopsy specimens and found that LOH at 9p was more common than LOH at 17p in diploid samples. The biopsy samples contained a mosaic of patterns of ...

We have previously reported that focal intraspinal N-methyl-d-aspartate (NMDA) iontophoresis in the frog elicits a motor output, which is organized in terms of its constituent isometric force directions at the ipsilateral ankle and its topography. Furthermore, the associated EMG patterns can be reconstructed as the linear combinations of seven muscle synergies, labeled A to G. We now focus on o...

BACKGROUND/AIM It is a general opinion that the biggest number of colorectal carcinoma (CRC) develops with the malignant alteration of colorectal adenomas (adenoma carcinoma sequence). Malignant potential of adenoma is in the function of its size, histological structure and the grade of dysplasia. An adequate analysis of colorectal adenomas helps their definition and timely removal, which signi...

Abstract Background The double inversion recovery (DIR) pulse sequence was introduced several years ago and since that it grew important value in clinical neuroimaging. We aimed to assess the added of evaluation epileptic patients. Results In mesial temporal sclerosis, measured contrast parameters (SNR, CR, CNR AI) were found be significantly higher DIR than FLAIR T2 sequences. cases focal cort...

We describe here a fetus with holoprosencephaly and signs of caudal deficiency sequence. Chromosome examination showed a de novo balanced reciprocal translocation (7;22) (q36;q11) with loss of the derivative chromosome 22 in 50% of the cells examined. The present report and available published data indicate that the terminal region of the long arm of chromosome 7 contains genes implicated in th...