BACKGROUND Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes constituting a large proportion of peripheral blood T cells expressing αβ T-cell receptor in humans. In this study, we aimed to investigate their involvement in systemic lupus erythematosus (SLE). METHODS Peripheral blood MAIT cells from patients with SLE were assessed for their frequency, activation markers, a...

Abstract Due to their position in the pulmonary mucosa, CD8 +tissue resident memory T cells (T RM) act as sentinels that rapidly respond to, and mediate protection against, respiratory viruses. In mice, RMhave been shown at barrier sites by producing cytokines, chemokines, performing cell lysis. However, humans, less is known about effector functions of virus-specific lung +T RM. Using from hea...

Abstract CD154 pathway blockade has been shown to significantly improve graft survival in transplantation. Recently, CD11b was identified as an alternate receptor for CD154. CD154:CD11b interactions promote rejection by increasing the recruitment of innate and adaptive immune cells into allograft. However, effects on protective response infection during immunosuppression not elucidated. To addr...

Since their onset, display technologies have proven useful for the selection of antibodies against a variety of targets; however, most of the antibodies selected with the currently available platforms need to be further modified for their use in humans, and are restricted to accessible antigens. Furthermore, these platforms are not well suited for in vivo selections. We present here a novel cel...

objective: adipose derived stem cells (ascs), as one of the important stromal cells in the tumor microenvironment, are determined with immunomodulatory effects. the principle aim of this study was to evaluate the immunosuppressive effects of ascs on natural killer (nk) cells. materials and methods: in this experimental study, we assessed the expressions of indolamine 2, 3-dioxygenase (ido1), id...

The phenotypic features acquired subsequent to antigen-specific stimulation in vitro were evaluated by means of the kinetic expressions of CD69 and CD25 activation molecules on T lymphocytes and assayed by flow cytometry in response to PPD, Ag85B, and ferritin in PPD-positive healthy control individuals. In response to PHA, CD69 staining on both CD4+ and CD8+ T cells became initially marked aft...

Atrial fibrillation (AF) is a common disease with a poorly understood pathophysiological mechanism. Increasing evidence indicates that AF may be associated with immunologic inflammation responses, but it remains unclear whether activation of peripheral blood CD3(+) T-lymphocytes plays a role in the pathogenesis of AF. The aim of this study was to evaluate this phenomenon. Fifty paroxysmal AF pa...

In the absence of antigen, memory T helper (Th) cells are maintained in a resting state. Recently it has been shown that bone marrow (BM) is a major reservoir of resting memory Th cells. In a given immune response, less than 10% of the activated CD4 T cells are recruited to the pool of resting BM memory Th cells. Here we review recent evidence that CD69 and CD49b control homing of memory Th cel...

Human immunodeficiency virus (HIV)-resistant commercial sex workers provide a unique opportunity to study correlates of protection associated with natural resistance to HIV infection. Emerging data from studies of these individuals and other uninfected individuals who have been exposed to HIV suggest that low levels of immune activation may contribute to protection against infection. In the pre...