apoptosis is a complex network of biochemical and molecular pathway with fine regulatory mechanisms that control the death event during several pathological situations in multi cellular organisms. it is the part of normal development that occurs in a variety of diseases and is known as aberrant apoptosis. pancreatic β cell apoptosis is also a pathological feature which is common in both type 1 ...

Background: Molecular targeted therapy by different cell death inducers are recently considered in cancer therapy. The aim of this study was to compare the effect of cisplatin and inositol trisphosphate kinase inhibitor (caffeine) on human breast cancer cell line (MCF-7). The pattern of cell death in MCF-7 cells following the exposure to cisplatin and caffeine in individual and combination form...

background and aims: coxsackievirus b3 (cvb3) is the most common agent known to cause viral myocarditis. the viral genome encodes a single polyprotein that is cleaved to produce several proteins by virally encoded proteases. most of this proteolytic processing is catalyzed by a cysteine protease called 3c. the 3c protease plays major role in viral replication and cellular damage. methods: to un...

apoptosis or programmed cell death is a gene regulated phenomenon which is important in both physiological and pathological conditions. it is characterized by distinct morphological features including chromatin condensation, cell and nuclear shrinkage, membrane blebbing and oligonucleosomal dna fragmentation. although, two major apoptotic pathways including 1) the death receptor (extrinsic) and...

Seizure activity has been proposed to result in the generation of reactive oxygen species (ROS), which then contribute to seizure-induced neuronal damage and eventually cell death. Although the mechanisms of seizure-induced ROS generation are unclear, mitochondria and cellular calcium overload have been proposed to have a crucial role. We aim to determine the sources of seizure-induced ROS and ...

background: zinc has significant effects on structural and functional activities of many proteins and enzymes involved in biological activities, especially the regulation of immune-system. symptoms of zinc toxicity include nausea/vomiting, fever, cough, diarrhea, fatigue, neuropathy, and dehydration. further signs include growth retardation, altered iron function, anemia, copper deficiency, dec...