Background: A prerequisite for successful embryo implantation is adequate preparation of receptive endometrium and the establishment and maintenance of a viable embryo. The success of implantation further relies upon a two-way dialogue between the embryo and uterus. However, molecular bases of these preimplantation and implantation processes in humans are not well known. Materials and Methods: ...

Abstract T cells have a prominent role in the pathogenesis of atherosclerosis, although their exact function remains elusive. Here, we pursued network-driven approach to identify cell-associated gene programs driving transition from low- high-risk human plaques. In this study 43 carotid arterial plaques were collected and stratified based on absence (low-risk) or presence (high-risk) intraplaqu...

Multicellular tissues are the building blocks of many biological systems and organs. These not static, but dynamically change over time. Even if overall structure remains same there is a turnover cells within tissue. This dynamic homeostasis maintaned by numerous governing mechanisms which finely tuned in such way that tissue homeostatic state, even across large timescales. Some these include c...

Mitochondria have long been considered as crucial organelles, primarily for their roles in biosynthetic reactions such as ATP synthesis. However, it is becoming increasingly apparent that mitochondria are intimately involved in cell signalling pathways. Mitochondria perform various signalling functions, serving as platforms to initiate cell signalling, as well as acting as transducers and effec...