Processed antigen reacts selectively with lymphocytes bearing .appropriate surface immunoglobulin molecules resulting in the clonal proliferation of these cells, produc­ing circulating immunoglobulin (humoral immunity) or non-circulating immunoglobulins (cellular immunity).  High levels of circulating immunoglobulins (lgM & lgG) occur in protozoa and helminths infections. Reaginic antibodies a...

Immunity in the infant has been extensively studied in the past and numerous investigations have been made into the development of specific immunity, the production of antibody and the passive transfer of antibody from the mother. On the other hand comparatively little work has been devoted to elucidating the complexities of the cellular response since Tunnicliff (1910) observed that phagocytos...

An in vitro model of cellular immunity in the guinea pig was established. Animals were immunized with tubercle bacilli, bovine gamma globulin, or picrylated human serum albumin in complete Freund's adjuvant. Oil-induced peritoneal exudates from immune and control animals were cultured overnight with and without specific antigen. The cultures were washed and the macrophage monolayers were infect...