objective(s) the purpose of this study was to investigate the role of oxidative stress in purkinje cell neurotoxicity ofethanol-treated rat. materials and methods male rat pups 4-day-old was used in this study. ethanol was administered to rat pups at a dose of 6 g/kg from postnatal days (pds) 4 to 5.  pups were killed 90 min after the second alcohol treatment on pd 5 by decapitation and the bra...

objective(s): the aim of the present study was to evaluate antioxidant and methyl donor effects of betaine in cerebellum following levodopa and benserazide administration in rats. materials and methods: sprague-dawley male rats were treated with levodopa (ld), betaine (bet), levodopa plus betaine (ld/bet), levodopa plus benserazide (ld/ben), levodopa plus betaine-benserazide (ld/bet-ben), and t...

conclusions considering that neuronal function highly depends on environmental conditions, any adverse alteration may affect the function and morphology of neurons. in this regard, our results showed the adverse effects of protein malnutrition on the morphology of the purkinje cells of cerebellum. results the low-protein group did not gain weight as much as control group (p < 0.05). the diamete...

Drug abuse has been claimed to cause the loss of neurons and reduction of volume in both the adult and developing brain. This study examined cortex volumes in cerebrum and cerebellum of male rats that were dependent on morphine using unbiased stereological counting methods and systematic random sampling technique. Our goal was to test whether short time exposure to morphine can affect the corte...

Purpose: To study the specific content (per 1 g of tissue) reduced glutathione and activity enzyme antioxidant protection peroxidase conjugated with it in various structural functional parts rat brain when exposed to ionizing radiation at a dose 6 Gy. Material methods: The studies were carried out on white outbred rats subjected single total γ-radiation an average lethal determined irradiated a...