certain extent. In his landmark paper on the pathological signatures of cerebrovascular amyloid deposition, Stefanos Pantelakis from the Geneva Brain collection, descripted small arterioles and capillaries within the cerebellar cortex affected by this pathology [2] . Similar findings were also reported in a Japanese autopsy study, which found that 14.3% of cerebellar bleeds were associated with...

BACKGROUND AND PURPOSE Accumulation of amyloid-β in cerebral blood vessels occurs in familial and sporadic forms of cerebral amyloid angiopathy and is a prominent feature of Alzheimer disease. However, the functional correlates of the vascular pathology induced by cerebral amyloid angiopathy and the mechanisms involved have not been fully established. METHODS We used male transgenic mice expr...

Efforts are underway for early-phase trials of candidate treatments for cerebral amyloid angiopathy, an untreatable cause of haemorrhagic stroke and vascular cognitive impairment. A major barrier to these trials is the absence of consensus on measurement of treatment effectiveness. A range of potential outcome markers for cerebral amyloid angiopathy can be measured against the ideal criteria of...

An abnormally low level of cystatin C in the cerebrospinal fluid is a diagnostic marker for the hereditary form of brain hemorrhage associated with amyloidosis that was first identified in Iceland. We developed an assay for cystatin C to use in the diagnosis of patients with cerebral amyloid angiopathy and brain hemorrhage. This test consists of a sandwich enzyme-linked immunosorbent assay usin...

Brain of a 66 year old woman with a four year history of progressive dementia with episodes of encephalopathy. Opposite: Multiple small, cystic, and occasionally confluent cortical scars (arrows) were restricted to the cerebrum and were due to cerebral amyloid angiopathy. Histological examination of the cortex in the postmortem brain showed numerous neuritic plaques and neurofibrillary tangles ...

To cite: Sharma N, Vyas S. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/ bcr-2013-201558 DESCRIPTION A 72-year-old man presented with headache, vomiting and diminution of vision. There was no history of smoking, diabetes mellitus, hypertension or use of aspirin or recreational drugs. The general physical examination, pulse, blood pressure, chest and cardiovascular ...

OBJECTIVE To investigate the distribution of lobar microbleeds over the different lobes, taking into account lobar volume and clustering effects of multiple microbleeds. DESIGN Population-based, cross-sectional analysis. SETTING The Rotterdam Scan Study. PARTICIPANTS A total of 198 persons (age range, 61-95 years) with lobar microbleeds. MAIN OUTCOME MEASURES Distribution of microbleeds...

#### Notable in Neurology This Week This issue features an article that evaluates the association between silent myocardial infarction and subsequent ischemic stroke, a review discusses diagnosis, pathophysiology, management of transient focal neurologic episodes related to cerebral amyloid angiopathy. A featured Special Article presents 2020 update American Academy Neurology's Parkinson disea...