Introduction: Nucleobinding-2 (NUCB2) or nesfatin-1, a newly identified anorexigenic peptide, has antioxidant, anti-inflammatory, and anti-apoptotic properties. Brain ischemia-reperfusion induces irreversible damages, especially in the hippocampus area. However, the therapeutic effects of NUCB2 have not been well investigated in cerebral ischemia. This study was designed for the first time to i...

background: pentoxifylline (ptx) is used in human for intermittent claudication and cerebral vascular disorders including cerebrovascular dementia. it also inhibits the synthesis of tumor necrosis factor-α (tnf-α), which is believed to be neurotoxic in animal models of cerebral ischemia. the objective of this study was to examine the role of ptx on ischemia/reperfusion injures in rat model of t...

One of the newest methods to reduce cerebral ischemia damages is cell therapy. The aim of this study is to evaluate the effect of Sertoli cell transplantation on ischemia-induced injuries in animal models of stroke. Rats were divided into four groups: transplant+ischemia, ischemia, sham, and control. Sertoli cells were separated from the other testis of rats and cultured. Unilateral Sertoli cel...

Introduction: Development of brain edema following focal cerebral ischemia exacerbates primary ischemic injury. Blood brain barrier (BBB) opening is an important part of edema named as vasogenic brain edema. In this study, quantitative alterations of BBB permeability is experimentally evaluated using transient focal cerebral ischemia in the rat. Methods: Two groups of male rats (ischemic and sh...

Cerebral ischemia causes death of millions people all over the world, annually and also suffering more people from neurological deficits and neuromuscular disorders. In our country, 250 to 300 people experience mild to severe stroke, daily. In this study we reviewed 120 original paper selected from PubMED database. Our keywords were erythropoietin, anti-inflammatory, stroke, neuropathy and cere...

introduction: anesthetic agents, blood pressure, arterial ph and blood gases have found to influence on the pathophysiology of experimental stroke. despite, there are very few comparative studies about effects of anesthetic agents in animal model of cerebral ischemia. therefore, in this study, we investigated the effects of chloral hydrate and pentobarbital anesthesia, as comparative study, on ...

objective(s): cerebral ischemia is often associated with cognitive impairment. oxidative stress has a crucial role in the memory deficit following ischemia/reperfusion injury. α-terpineol is a monoterpenoid with anti-inflammatory and antioxidant effects. this study was carried out to investigate the effect of α-terpineol against memory impairment following cerebral ischemia in rats. materials a...

objective: oxygen free radicals may be implicated in the pathogenesis of ischemia reperfusion damage. the beneficial effects of antioxidant nutrients, as well as complex plant extracts, on cerebral ischemia-reperfusion injuries are well known. this study was conducted to determine the effects of the hydro-alcoholic root extract of withania coagulans on ca1 hippocampus oxidative damages followin...