Introduction: Development of brain edema following focal cerebral ischemia exacerbates primary ischemic injury. Blood brain barrier (BBB) opening is an important part of edema named as vasogenic brain edema. In this study, quantitative alterations of BBB permeability is experimentally evaluated using transient focal cerebral ischemia in the rat. Methods: Two groups of male rats (ischemic and sh...

Background: Angiotensin II (Ang II) has an important role on cerebral microcirculation however, its direct roles in terms of ischemic brain edema need to be clarified. This study evaluated the role of central Ang II by using candesartan, as an AT1 receptor blocker, in the brain edema formation and blood-brain barrier (BBB) disruption caused by ischemia/reperfusion (I/R) injuries in rat. Methods...

Safranal is a monoterpene aldehyde found in saffron (Crocus sativus L.) petals. It has been previously reported that safranal has a wide range of activities such as antioxidant and anti-inflammatory effects. In this study, we examined the effect of safranal on brain injuries in a transient model of focal cerebral ischemia. Transient focal cerebral ischemia was induced by middle cerebral artery ...

objective(s): carthamus tinctorius l. (ct) or saffloweris widely used in traditional chinese medicine. this study investigated the effects of ct extract (cte) on ischemia–reperfusion (i/r) brain injury and elucidated the underlying mechanism. materials and methods: the i/r model was conducted by occlusion of both common carotid arteries and right middle cerebral artery for 90 min followed by 24...

Objective(s): Carthamus tinctorius L. (CT) or saffloweris widely used in traditional Chinese medicine. This study investigated the effects of CT extract (CTE) on ischemia–reperfusion (I/R) brain injury and elucidated the underlying mechanism. Materials and Methods: The I/R model was conducted by occlusion of both common carotid arteries and right middle cerebral artery for 90 min followed by 24...

objective(s):global cerebral ischemia-reperfusion injury causes loss of pyramidal cells in ca1 region of hippocampus. in this study, we investigated the possible neuroprotective effects of the ethanol extract of cyperus rotundus (eecr) on a model of global transient ischemia in rat, by evaluating the pathophysiology of the hippocampal tissue and spatial memory. materials and methods: treatment ...

Objective(s):Global cerebral ischemia-reperfusion injury causes loss of pyramidal cells in CA1 region of hippocampus. In this study, we investigated the possible neuroprotective effects of the ethanol extract of Cyperus rotundus (EECR) on a model of global transient ischemia in rat, by evaluating the pathophysiology of the hippocampal tissue and spatial memory. Materials and Methods: Treatment ...

objective(s) the brief interruption of cerebral blood flow causes permanent brain damage and behavioral dysfunction. the hippocampus is highly vulnerable to ischemic insults, particularly the ca1 pyramidal cell layer. there is no effective pharmacological strategy for improving brain tissue damage induced by cerebral ischemia. previous studies reported that pentoxifylline (ptx) has a neuroprote...

Objective: Oxygen free radicals may be implicated in the pathogenesis of ischemia reperfusion damage. The beneficial effects of antioxidant nutrients, as well as complex plant extracts, on cerebral ischemia-reperfusion injuries are well known. This study was conducted to determine the effects of the hydro-alcoholic root extract of Withania coagulans on CA1 hippocampus oxidative damages followin...