Hu, X. 2001. Molecular Pathogenesis of Cervical Carcinoma: Analysis of Clonality, HPV16 Sequence Variations and Loss of Heterozygosity. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1080. 76pp. Uppsala. ISBN 91-554-5127-6 A previous model of morphological pathogenesis assumed that cervical carcinoma is of monoclonal origin and prog...

INTRODUCTION Malignant transformation of sex-steroid dependent tissues is associated with the loss of expression of sex steroid receptors as well as of the tumor suppression gene p53. The aim of this study is to evaluate the expression of sex-steroid receptors, p53 and Ki-67 in specimens from pre-malignant and malignant cervical epithelial lesions throughout the menstrual cycle. MATERIAL AND ...

background endometrial carcinoma is a highly prevalent gynecologic malignancy. the international federation of gynecology and obstetrics (figo) staging system underwent significant revision on 2009. key changes in the figo staging system include simplification of stage i endometrial cancer and removal of cervical mucosal invasion as a separate stage. mri is a noninvasive diagnostic method for p...

Background: Gynecological carcinomas form a significant proportion of all malignancies in women across the globe. These are associated with an increase in the serum concentrations of certain tumor markers such as cancer antigen (CA)125, CA19.9 and carcinoembryonic antigen (CEA) that correlate with the tumor burden. Methods: Preand post-treatment serum levels of CA125, CA19.9 and CEA were determ...

OBJECTIVES There is no generally accepted treatment strategy for cervical esophageal carcinoma. The purpose of this study was to evaluate the operative outcomes of reconstruction after resection of cervical esophageal and hypopharynx-esophagus junction carcinoma with larynx preservation. METHODS We retrospectively reviewed the data of 79 patients with carcinoma of the hypopharynx-esophagus ju...

  Amoebiasis of the uterine cervix is an extremely rare entity and presentation as carcinoma cervix has only been reported once in the extensively searched English literature. It can clinically simulate cervical malignancy by virtue of surface papillomatous and overall ulcerated and necrotic appearance. We present a case of amoebic cervicitis in a 55-year old female which was suspected to be a...

In this study, the existence of vasculogenic mimicry (VM) in cervical squamous cell carcinoma was investigated. To this end, the relationship between hypoxia-inducible factor 1α (HIF-1α) and the development, infiltration, and metastasis of cervical squamous cell carcinoma was studied. Between January 2010 and December 2010, 67 human cervical squamous carcinoma tissue samples were collected and ...

X-linked inhibitors of apoptosis (XIAP) and second mitochondria-derived activator of caspase (Smac) have been widely reported to serve roles in the development of cervical carcinoma. The present study analyzed the associations between the expression levels of XIAP and Smac in normal cervical epithelium, cervical intraepithelial neoplasia (CIN) and cervical carcinoma. Immunohistochemistry staini...

Interleukin-5 (IL-5) levels were significantly higher in vaginal washing fluids from patients with cervical carcinoma than in those from patients with carcinoma in situ and controls. Tumor necrosis factor alpha levels did not differ among the three groups. Detection of IL-5 in cervical secretions may be a useful marker for evaluating aggressive local immune response in cervical carcinoma.