OBJECTIVE The aim of this study was to identify changes in the cervical transcriptome in the human uterine cervix as a function of ripening before the onset of labor. STUDY DESIGN Human cervical tissue was obtained from women at term not in labor with ripe (n = 11) and unripe (n = 11) cervices and profiled using Affymetrix GeneChip HGU133Plus2.0 arrays. Gene expression was analyzed using a mo...

Misoprostol, a prostaglandin E1 derivative, has been widely used in nonpregnant women because of its cervical ripening and uterotonic effects. A large number of studies have demonstrated its effectiveness in enhancing ease of cervical dilation. This review article describes its pharmacokinetic profile and the relationship between prostaglandins and cervical ripening and uterine contraction and ...

Cervical dilatation is a key event for successful vaginal delivery of young ones that occur just before parturition. Failure of cervical dilatation due to alterations in cervical ripening mechanism or insufficient uterine contraction poses problems in delivery of fetus. Cervical ripening is a multifactorial process which is an outcome of hormonal regulation, inflammatory process and enzymatic b...

background: the most favorable method for cervical ripening is not fully agreed upon by practitioners; however, vaginal administration of isosorbide mononitrate (imn) is considered a low‑risk method of labor induction for pregnant women at full term. our study was designed to assess the effect of imn on cervical ripening and labor induction among primiparous women in iran. materials and methods...

Since uterine cervical ripening is an active biochemical process similar in part to an inflammatory reaction, nitric oxide (NO) has been proposed as a key mediator of this event. However, the mechanism by which NO modulates human cervical ripening has not been fully elucidated. In the present study we investigated the presence of NO synthases in human uterine cervix by immunohistochemistry and ...

background: an increasing success in induction of labor and subsequent termination of pregnancy in presence of unfavorable cervix requires cervical ripening in order to reduce complications and to diminish the rate of cesarean sections as well as the duration of labor.  however, there is no consensus on the efficiency of conventional methods for cervical ripening.   objective: to determine and ...

Aims. Prostaglandin E2 is the most commonly used drug for cervical ripening prior to labour induction. However, there are concerns regarding uterine tachysystole and nonreassuring fetal heart (N-RFH). Isosorbide mononitrate (IMN) has been used successfully for cervical ripening. The present study was conducted to compare the two drugs for cervical ripening at term in hospital. Methods. Two hund...

Background: Cervical ripening, before induction of labour, is needed to increase the success of labour induction, to reduce complications and to diminish the rate of cesarean section and duration of labour. Pharmacological preparations are in widespread use for cervical ripening but are not free from side-effects and complications. Mechanical methods, i.e. the use of Foley’s catheter balloon, t...

sists mainly of collagen, hyaluronan, and proteoglycan. During gestation, it must close firmly to retain the fetus in the uterus. It undergoes ripening and dilatation at term, forming a parturient canal so that delivery can occur. During ripening, there are increases of collagen degradation in connective tissues, and proteoheparan sulfate, while decorin decreases. Inflammatory mediators, such a...