A novel oral controlled delivery system for propranolol hydrochloride (PPL) was developed and optimized. The in vitro dissolution profiles of sustained-release matrix tablets of racemic PPL were determined and compared with the United States Pharmacopeia (USP) tolerance specifications for Propranolol Hydrochloride Extended-Release Capsules. The influence of matrix forming agents (native dextran...

Sophorolipids (SLs) are glycolipid biosurfactants that have been shown to display anticancer activity. In the present study, we report anti-proliferative studies on purified forms of novel SLs synthesized using cetyl alcohol as the substrate (referred as SLCA) and their anticancer mechanism in human cervical cancer cells. Antiproliferative effect of column purified SLCA fractions (A, B, C, D, E...

In this research, the micellar behavior of a cationic surfactant, cetyl trimethyl ammonium bromide (CTAB) and an nonionic surfactant, polysorbate 20 (Polyoxyethylene (20) sorbitan monolaurate) in different alcohol solutions media was investigated over the temperature range 293.15-313.15 K. The interaction between two surfactants in binary systems can be determined by calculating the values of t...

Effects of formulation parameters on the fractional release profile of diclofenac sodium from matrices having the manufacturing formulation ingredients are studied. As a content of cetyl alcohol (rate controlling agent) in the matrix increases, the fractional release decreases. The fractional release increases either by increasing sucrose content outside the granule or by decreasing sucrose...

In this study three cream formulations were compared in order to assess the influence of different kind of excipients on the skin barrier and stratum corneum hydration. The first cream was formulated based on lipophilic emollients: petrolatum, paraffin oil, cetylstearilic alcohol, cetyl palmitate and paraffin, the second cream was formulated based on emollients (cetylstearilic alcohol, cetyl pa...

Declining dairy cow fertility, largely attributable to increasing milk yields, is of major concern to dairy farmers worldwide. New tools for reproductive management, to replace exogenous hormones, would be of great interest. Chemical communication in cattle has been suggested to cause modifications of the oestrous cycle. Here, reproductive parameters were monitored in ten dairy heifers during f...