Aim. To compare changes in the complement system C3-glomerulopathy (C3-GP) and atypical hemolytic uremic syndrome (aHUS) after relief of an acute episode thrombotic microangiopathy.
 Materials methods. The study included 8 patients diagnosed with C3-GP aHUS remission. blood levels components were determined: C3, C4, C3a, C5a, factor H (CFH), B (CFB), membrane-attacking complex (MAC), antib...

background: inappropriate activation or blockage of the inhibition of complement system could cause tissue damages in autoimmune diseases particularly rheumatoid arthritis (ra). defect in complement component regulation may cause damages to tissues, on the other hand, or the damaged tissue might affect the unnecessary activation of complement components.   objective: to investigate the expressi...

The complement system consists of more than 30 proteins and has 3 types of activation pathways: classical, lectin and alternative pathways. The complement system not only has a role in innate immunity but also works as an antibody-dependent effecter to eliminate pathogens. It is useful to measure serum levels of CH50, C3 and C4 in patients with immune-mediated diseases. While increased levels o...

In the absence of specific antibody, opsonization of Streptococcus pneumoniae may be mediated by the alternative complement pathway (AP) or by C-reactive protein (CRP) via C1 binding. To determine the role of these mechanisms in pneumococcal (PNC) disease, we studied 19 patients with differing severities of PNC infection. C4 and CRP levels and zymosan-induced consumption of 50% hemolytic comple...

The measurement of total haemolytic complement is of diagnostic value in the rheumatic diseases. A method which is easier to perform than that of Kabat and Mayer (Experimental Immunochemistry, 2nd ed., Thomas, Springfield, Ill.) is described. A unit based on the mean value of the complement activities of normal sera is proposed to replace CH50 units. Other steps by which standardisation of the ...

The nonspecific immune response plays an important role in organism's defense against a variety of pathogens. Two major factors this process are blood serum lysozyme and alternative pathway complement activation (APCA). Over the past few decades, application various substances, targeting improved levels natural immunity have become part mainstream trends livestock rearing programs. current stud...