abstract: oxidation might be regarded as one of the most important reaction in oils and fats. prooxidants namely iron and copper intensify and catalyze the oxidation while the chelating agents might retard or delay this process. citric acid, phosphoric acid, some of phenolic compounds and phospholipids are considered as the compounds that chelate the prooxidant metals and through this mechanism...

background: patients with transfusional iron overload have depended on iron chelation therapy and improving chelation regimens have been of the highest priority. the aim of this study was to compare effect of combined versus monotherapy with deferoxamine (dfo) and deferiprone (dfp) in iron overloaded beta thalassemia (bt) major patients materials and methods we studied 36 bt major patients (mea...

ABSTRACT: Oxidation might be regarded as one of the most important reaction in oils and fats. Prooxidants namely iron and copper intensify and catalyze the oxidation while the chelating agents might retard or delay this process. Citric acid, phosphoric acid, some of phenolic compounds and phospholipids are considered as the compounds that chelate the prooxidant metals and through this mechanism...

The main aim of this study was to prepare apple pomace polyphenolic extract (APPE- referred to as a core) loaded into biodegradable and commercially available natural polymer such as maltodextrin (MD-referred to as a shell). The polymer coating potentially improves its low stability and bioavailability and also directs the control release of the encapsulated material. The MD-nanoparticles (NPs)...

Background: β-thalassemia is an autosomal hemoglobinopathy with inconsistent universal distribution. Among patients with thalassemia diverse non-siderotic complications distinctly influence the attribute of life, including zinc deficiency due to varied etiologies. The objective of the present study was to determine zinc levels in patients with β-thalassemia major and its correlation with mat...

objective: in this study the susceptibility of candida albicans to inhibitory effect of polyphenols under varying time (24 and 48 hours) conditions were evaluated. materials and methods: green tea leaf polyphenols were extracted and analyzed by chromatography. among polyphenols, catechin showed stronger antifungal activity against c. albicans ptcc-5027. catechin's mic90 (the concentration of c...

Background: Effective management of iron overload in patients receiving long-term blood transfusion requires assessment and monitoring of both severity of iron overload and excessive iron chelation. We aimed to evaluate the efficacy and safety of Deferasirox (DFX) in chelation naive patients with transfusion dependent thalassemia and sickle cell disease. Methods: Chelation naive patients with ...

Cocoa is a rich source of high-quality antioxidant polyphenols. They comprise mainly catechins (29%-38% of total polyphenols), anthocyanins (4% of total polyphenols) and proanthocyanidins (58%-65% of total polyphenols). A growing body of experimental and epidemiological evidence highlights that the intake of cocoa polyphenols may reduce the risk of cardiovascular events. Beyond antioxidant prop...