A biotransformation approach using microbes as biocatalysts can be an efficient tool for the targeted modification of existing antibiotic chemical scaffolds to create previously uncharacterized therapeutic agents. By employing a recombinant Streptomyces venezuelae strain as a microbial catalyst, a reduced macrolide, 10,11-dihydrorosamicin, was created from rosamicin macrolide. Its chemical stru...

Purified isothiocyanates from cruciferous plants (Brassicacea, Syn. Cruciferae) plants were evaluated against 15 isolates of methicillin-resistant S. aureus isolated from diabetic foot-ulcer patients aiming the study of the potential usage of allyl-isothiocyanate, benzyl-isothiocyanate and 2-phenylethyl-isothiocyanate against this important bacteria. Disc diffusion and minimum inhibitory concen...

Removal of heavy metals from wastewater needs advance chemical technology and is more expensive too. The cheaper alternative for this is the bioremediation using heavy metals resistant microorganisms. In this study, 10 heavy metal resistant bacteria were isolated from oxidation ditch of wastewater treatment plant of Bagmati Area Sewerage Project. These include chromium resistant Staphylococcus ...

This paper discusses the rule that polymorphic transformation does not occur in heat-resistant steels and alloys. The basic theoretical principles used to analyze most diverse processes occurring heat resistant alloys have been analyzed described. crystallization process of various alloys, formation decomposition austenite, new phase formed during operations chemical-heat treatment are Extensiv...

conclusions in the present study, we found a high prevalence of mrsa at the hospitals studied. the findings emphasized the increased prevalence of mrsa isolates containing different toxin and adhesion genes, probably accompanied by antimicrobial resistance. infection with such isolates worsens the clinical outcomes as well as the morbidity and mortality rates in hospitalized patients in icus. m...