Background & Aims of the Study: A high nitrate and arsenic concentration in water resources represent a potential risk to the environment and public health. The present work improved a chemo-physically modified activated carbon derived from walnut shells as an adsorbent to improve nitrate and arsenic removal ability from water. Materials & ...

The majority of small cell lung cancer (SCLC) patients demonstrate initial chemo-sensitivity, whereas a distinct subgroup of SCLC patients, termed chemo-refractory, do not respond to treatment. There is little understanding of how to distinguish these patients prior to disease treatment. Here we used gene expression profiling to stratify SCLC into subgroups and characterized a molecular phenoty...

Circulating tumor DNA (ctDNA) provides a promising noninvasive alternative to evaluate the efficacy of neoadjuvant chemotherapy (NCT) in breast cancer. Herein, we collected 63 tissue (aspiration biopsies and resected tissues) 206 blood samples (baseline, during (Chemo), after (Post-Chemo), operation (Post-Op), follow-up) from 32 patients, preformed targeted deep sequencing with customed 1021-ge...

To assess whether preoperative chemo-radiotherapy enhances the expression of vascular endothelial growth factor (VEGF) in patients with colorectal cancer, we investigated in vivo and in vitro the interactions between chemo-radiotherapy and the expression of VEGF, and their possible impact on distant metastasis. Cellular cytotoxicity in the colon cancer cell lines, LoVo, SW480 and Caco2, was det...

Pre-exposure prophylaxis (PrEP) with anti-viral drugs is currently in clinical trials for the prevention of HIV infection. Induction of adaptive immune responses to virus exposures during anti-viral drug administration, i.e., a "chemo-vaccination" effect, could contribute to PrEP efficacy. To study possible chemo-vaccination, we monitored humoral and cellular immune responses in nine rhesus mac...

Chemo-enzymatic hybrid process merging enzymatic cascade reactions of designed substrates with chemo- and site-selective synthetic manipulations allowed the chemo-enzymatic total syntheses jorunnamycin A saframycin A, in just 4 5 pots processes, respectively. Artificial variants installation various amino acids place l-Ala were systematically generated, demonstrating substantially broader subst...

In this era of minimal intervention dentistry, the changing concept of cavity preparation and the introduction of reliable adhesive materials have lead to the development of alternative methods of caries removal. Chemo mechanical caries removal (CMCR) involves the chemical softening of the carious dentine, followed by its removal with gentle excavation. This process removes only the infected ti...

Medical practitioners are recommending combination therapy in cancer for its various advantages. Combination therapy increases the efficacy of treatment due to its synergistic effects in cancer treatment. In this post-genomic era, microRNAs (miRNAs) are receiving attention for their role in human disease and disease therapy. In this review, we discuss the combination of miRNAs and chemotherapeu...