Cancer Chemo-Immunotherapy In article number 2103497, Yubin Huang, Dongfang Zhou, and co-workers demonstrate an engineered endogenous tumor-associated macrophages (TAMs)-targeting biomimetic nano-red-blood-cell (RBC) system to deliver chemotherapeutic doxorubicin oxygen for enhanced cancer chemo-immunotherapy. TAMs-targeting depletion hypoxia alleviation synergistically reprogram the tumor immu...

Background: The present study was undertaken in patients of carcinoma cervix to evaluate the Implication of chemo radiotherapy on status of oxidative stress biomarker such as protein carbonyl, lipid hydro peroxide and antioxidants defence mechanism of melatonin and total thiol levels. Methodology: Patients were delivered radiotherapy by external beam radiotherapy (EBRT) followed by brachytherap...

INTRODUCTION Endothelial cell migration and proliferation play an important role in the growth and development of new blood vessels and endothelium healing. This process occurs in response to injury, inflammation and immune reactions. Dysfunction of the endothelium may play a significant role in development and progression of cardiovascular disease related to sleep-disordered breathing. The aim...

Background & Aims of the Study: A high nitrate and arsenic concentration in water resources represent a potential risk to the environment and public health. The present work improved a chemo-physically modified activated carbon derived from walnut shells as an adsorbent to improve nitrate and arsenic removal ability from water. Materials & ...

The majority of small cell lung cancer (SCLC) patients demonstrate initial chemo-sensitivity, whereas a distinct subgroup of SCLC patients, termed chemo-refractory, do not respond to treatment. There is little understanding of how to distinguish these patients prior to disease treatment. Here we used gene expression profiling to stratify SCLC into subgroups and characterized a molecular phenoty...

Circulating tumor DNA (ctDNA) provides a promising noninvasive alternative to evaluate the efficacy of neoadjuvant chemotherapy (NCT) in breast cancer. Herein, we collected 63 tissue (aspiration biopsies and resected tissues) 206 blood samples (baseline, during (Chemo), after (Post-Chemo), operation (Post-Op), follow-up) from 32 patients, preformed targeted deep sequencing with customed 1021-ge...

To assess whether preoperative chemo-radiotherapy enhances the expression of vascular endothelial growth factor (VEGF) in patients with colorectal cancer, we investigated in vivo and in vitro the interactions between chemo-radiotherapy and the expression of VEGF, and their possible impact on distant metastasis. Cellular cytotoxicity in the colon cancer cell lines, LoVo, SW480 and Caco2, was det...

Pre-exposure prophylaxis (PrEP) with anti-viral drugs is currently in clinical trials for the prevention of HIV infection. Induction of adaptive immune responses to virus exposures during anti-viral drug administration, i.e., a "chemo-vaccination" effect, could contribute to PrEP efficacy. To study possible chemo-vaccination, we monitored humoral and cellular immune responses in nine rhesus mac...

‎let $d_{n,m}=big[frac{2n+1-sqrt{17+8(m-n)}}{2}big]$ and‎ ‎$e_{n,m}$ be the graph obtained from a path‎ ‎$p_{d_{n,m}+1}=v_0v_1 cdots v_{d_{n,m}}$ by joining each vertex of‎ ‎$k_{n-d_{n,m}-1}$ to $v_{d_{n,m}}$ and $v_{d_{n,m}-1}$‎, ‎and by‎ ‎joining $m-n+1-{n-d_{n,m}choose 2}$ vertices of $k_{n-d_{n,m}-1}$‎ ‎to $v_{d_{n,m}-2}$‎. ‎zhang‎, ‎liu and zhou [on the maximal eccentric‎ ‎connectivity ind...