INTRODUCTION There is a pressing need for effective measures to prevent the spread of cholera. Our systematic review assesses the effects of chemoprophylaxis in preventing cholera among exposed contacts. METHODS AND FINDINGS We considered published and unpublished reports of studies up to July 2011. For this we searched: PubMed (1966 to July, 2011), Embase (1980 to July 2011), Cochrane Centra...

i read the recent publication on children contacting with smear positive tuberculosis patients with great interest.[1] aminzadeh et al . concluded that the ‘strategy of six months of supervised isonicotinylhydrazine (inh) chemoprophylaxis is successful, particularly in children who are at high risk to progress to the disease, following exposure.[1] i agree with the usefulness and effectiveness ...

Background: Colorectal cancer (CRC) is the second most common lethal cancer in the Western world. There is a 10 to 20 years lead time from normal mucosa to carcinoma which offers a window of opportunity to modify and prevent the outcome of CRC, with its incipient morbidity and mortality. Objective: To review the evidence for chemoprophylaxis in CRC, identify currently utilized agents and determ...

Background: Colorectal cancer (CRC) is the second most common lethal cancer in the Western world. There is a 10 to 20 years lead time from normal mucosa to carcinoma which offers a window of opportunity to modify and prevent the outcome of CRC, with its incipient morbidity and mortality. Objective: To review the evidence for chemoprophylaxis in CRC, identify currently utilized agents and determ...

Colorectal cancer (CRC) is the second most common lethal cancer in the Western world. There is a 10 to 20 years lead time from normal mucosa to carcinoma which offers a window of opportunity to modify and prevent the outcome of CRC, with its incipient morbidity and mortality. The objective of this paper is to review the evidence for chemoprophylaxis in CRC, identify currently used agents and de...

Rational thought or actions accord with reason and logic, and, certainly in the realm of science, verifiable evidence underpins those attributes. This issue of Travel Medicine and Infectious Diseases offers a meta-analysis of a series of clinical trials of primaquine chemoprophylaxis reported 15e24 years ago [1]. Re-examining this evidence today serves the important purpose of considering the p...

Record-breaking and devastating rainfall events have occurred in the past decade. Rain and floods are considered the main risk factors for leptospirosis and several outbreaks have been reported following extreme weather events. In such situations, one possible intervention to prevent leptospirosis cases in high-risk groups is the use of chemoprophylaxis. However, not enough evidence of its effe...

BACKGROUND Infectious diseases are a leading cause of morbidity among travelers to resource-limited regions and primary prevention is a cornerstone to risk reduction. Chemoprophylaxis has been successfully utilized for specific diseases. METHODS We assessed self-reported compliance to daily chemoprophylaxis among deployed US military personnel. A 21 item self-completed questionnaire was compl...