IN THE TITLE COMPOUND (SYSTEMATIC NAME 7-chloro-2-methyl-amino-5-phenyl-3H-1,4-benzodiazepine 4-oxide dichloro-meth-ane monosolvate), C(16)H(14)ClN(3)O·CH(2)Cl(2), the seven-membered ring adopts a boat conformation with the CH(2) group as the prow and the two aromatic C atoms as the stern. The dihedral angle between the benzene rings is 75.25 (6)°. The crystal structure features centrosymmetric...

BACKGROUND Benzodiazepines are used to treat alcohol withdrawal (AW) but cause cognitive impairment, sedation, and ataxia, and interact with alcohol. Nonbenzodiazepine anticonvulsants are promising and possibly safer alternatives for the treatment of AW. OBJECTIVE To compare follow-up measures of Epworth Sleepiness Scale (ESS), Penn Alcohol Craving Scale (PACS), ataxia rating, and Clinical In...

Psychotic fear and anxiety disturbances are seen at a relatively high frequency in patients with schizophrenia. Atypical anti-psychotics are believed to show superior efficacy in reducing these symptoms. However, clinical and preclinical evidence regarding their anxiolytic efficacy has been mixed. In this study, we evaluated the possible anxiolytic property of two atypicals clozapine and olanza...

Atypical antipsychotics are also used in the treatment of anxiety-related disorders. Clinical and preclinical evidence regarding their intrinsic anxiolytic efficacy has been mixed. In this study, we examined the potential anxiolytic-like effects of risperidone and olanzapine, and compared them with haloperidol, chlordiazepoxide (a prototype of sedative-anxiolytic drug) or citalopram (a selectiv...

Census Designated Places (CDPs) are the Rodney Dangerfields of urban geography— they get no respect. The public does not understand them and researchers often overlook CDPs because they are seen as census-derived statistical artifacts as opposed to “real” places. Yet a CDP is a residential concentration whose population sees itself as belonging to a specific place, even if the place is not an o...

OBJECTIVE Analyze the use of appetite suppressants in Brazil in 2009, according to the characteristics of users, healthcare system, and other drugs. METHODS Pharmaconeconometric study of cross-sectional data to analyze the relationship between the use of appetite suppressants (mg/per capita) and the independent variables selected (gender, race/color, age, schooling, income, health insurance c...