Bleomycin is an antitumor antibiotic isolated from a strain of Streptomyces verticillus in 1966. It has been used successfully to treat a variety of tumors, including squamous cell carcinoma of the head and neck, cervix, and esophagus, as well as germ cell tumors and Hodgkin’s and non-Hodgkin’s lymphomas. The major limitation of bleomycin therapy is the potential for developing life-threatening...

Photodynamic Therapy (PDT) is considered a highly effective method to diagnose and treat a wide variety of premalignant and malignant processes characterized by the selective elimination of cancerous cells. PDT is based in the capability of some neoplastic cells to specifically accumulate a photosensitizer (Ps), which is photoactivated with local illumination of a specific wavelength. The Ps re...

The development of multiagent chemotherapy dramatically changed the prognosis of patients with advanced-stage Hodgkin lymphoma (HL). Although almost all of these patients died when treated with radiotherapy or single-agent chemotherapy, the fourdrug regimen MOPP (mustargen, oncovin, procarbazine, and prednisone) led to remission rates of more than 50% and an overall survival (OS) rate of more t...

The paper reviews new chemotherapy strategies for inter mediate and advanced stages of Hodgkin's disease as well as the implications of recent biological concepts and mathematical models which appear useful in the interpretation and design of new treatments. The development and the application of the Adriamycin-bleomycin-vinblastine-dacarbazine (ABVD) combi nation was based on critical rééval...

A little known group of Hungarian artists who were students at the Hungarian Academy of Fine Arts, Budapest in 1927‐1930, joined by a few artists from outside the Academy, were modernists. They explored the Soviet Russian avant‐garde and abstraction, and therefore were rejected by the mainstream, right‐wing official art in interwar Hungary. However, the strictly principled left‐wing Munka (Work...

This article examines archival collecting, taking as case studies two women’s archives. Drawing on their experiences building the collections of the Archives of Women in Science and Engineering (Iowa State University) and the Iowa Women’s Archives (University of Iowa), the authors explore how such efforts challenge traditional approaches to collecting. Proactive collecting, such as oral history...

Speech Recognition and Comfort Using Hearing Instruments with Adaptive Directional Characteristics in Asymmetric Listening Conditions. Ear & Hearing. 26(6):669-679, December 2005. Emma Mackenzie; Mark E. Lutman Links: Abstract | HTML | PDF (1.02 M) Abstract: Objective: Hearing instruments with adaptive directional microphone systems attempt to maximize speech-to-noise ratio (SNR) and thereby im...

The paper is concerned with tools for the quantitative analysis of nite Markov chains whose states are combinatorial structures. Chains of this kind have algorithmic applications in many areas, including random sampling, approximate counting, statistical physics and combinatorial optimisation. The e ciency of the resulting algorithms depends crucially on the mixing rate of the chain, i.e., the ...