OBJECTIVES To quantify the barrier sterols and image the lipid structures in the matrix of acquired cholesteatoma and compare the distribution with that found in stratum corneum from normal skin, with the goal to resolve their potential influence on cholesteatoma growth. METHODS High-performance thin-layer chromatography (HPTLC) was used to achieve a quantitative biochemical determination of ...

BACKGROUND: The histopathological characteristics of cholesteatoma are hyperproliferation and differentiation of the epithelium. The proliferative capacity of cholesteatoma was studied through the kinetics of the epithelium of cholesteatoma. The present study was undertaken to compare the rate of proliferation and apoptosis using immunohistochemistry with PCNA antigen and p53 protein in cholest...

INTRODUCTION Children cholesteatoma have been shown to demonstrate aggressive growth with greater extension and higher rates residual and recurrent disease compared with adults, due to anatomic and physiologic differences. AIM This study aimed to determine the clinical and pathological features of cholesteatoma in young children less than 7 years of age. MATERIAL AND METHODS Retrospective r...

BACKGROUND Cholesteatoma are cyst-like structures lined with a matrix of differentiated squamous epithelium overlying connective tissue. Although epithelium normally exhibits self-limited growth, cholesteatoma matrix erodes mucosa and bone suggesting changes in matrix protein constituents that permit destructive behaviour. Differential proteomic studies can measure and compare the cholesteatoma...

Cholesteatoma is an epidermoid cyst, which is most frequently found in the middle ear. The matrix of cholesteatoma is histologically similar to the matrix of the epidermoid cyst of the skin (atheroma); their epithelium is characterized by hyperproliferation. The c-MYC protooncogene located on chromosome 8q24 encodes a transcription factor involved in the regulation of cell proliferation and dif...

OBJECTIVE To determine whether endoscopic cholesteatoma removal can be performed efficiently and safely using a curved fiberoptic-based laser. BACKGROUND Angled instruments are required in endoscopic ear surgery to access recesses of the middle ear without extra drilling. Lasers are effective at ablating visible and microscopic cholesteatoma matrix and removing granulation tissue. STUDY DES...

Introduction: To reduce incidence of residual cholesteatoma following ear surgery; and to reduce the need for second look “open” mastoidectomy using endoscopic mastoidotomy. Ten-year retrospective chart review of 249 primary cholesteatoma cases (1994-2004) with a minimum follow-up of two years.  The first objective was to evaluate the effectiveness of otoendoscopy in reducing the incidence of “...

BACKGROUND The occurence of cholesteatoma and cochlear implant is rare. Secondary cholesteatomas may develop as a result of cochlear implant surgery. Primarily acquired cholesteatoma is not typically associated with congenital sensorineural hearing loss or cochlear implant in children. The occurrence of congenital cholesteatoma during cochlear implant surgery has never been reported before, par...

Background: Cholesteatoma is potentially dangerous condition as it can extend and erode into adjacent structures and can cause various serious complications. HRCT temporal bone very clearly depicts the anatomy of various small important structures in middle and inner ear cavity. Hence it is an excellent modality and investigation of choice in diagnosing and defining the extent of cholesteatoma....

OBJECTIVES/HYPOTHESIS To investigate the association of cleft conditions and the development of secondary cholesteatoma following middle ear ventilation tube insertion (MEVTI) in children. STUDY DESIGN A retrospective cohort study of all children born after 1980 who underwent at least one MEVTI in a Western Australian hospital from 1980 to 2009 using administrative health data. METHODS The ...