The pathogenic strain Italien and the apathogenic strain Ulster of Newcastle disease virus have been compared with respect to organ tropism and spread of infection in 11-day-old chick embryos. After infection of the endodermal layer of the chorioallantoic membrane by intra-allantoic inoculation with strain Italien, high virus titres are found in all extra-embryonic membranes and fluids and in t...

An in vitro quantitative assay of tumor cell invasion is described. The assay measures the rate at which [12sl]iododeoxyuridine-labeledtumor cells migrate through the chorioallantoic membrane of developing chicken em bryos. Invasion chambers were prepared from amber latex cylinders, chorioallantoic membrane, and thread liga tures. The chambers were placed in glass vials to rest on discs of phot...

An in vitro quantitative assay of tumor cell invasion is described. The assay measures the rate at which [125I]iododeoxyuridine-labeled tumor cells migrate through the chorioallantoic membrane of developing chicken embryos. Invasion chambers were prepared from amber latex cylinders, chorioallantoic membrane, and thread ligatures. The chambers were placed in glass vials to rest on discs of photo...

The chicken eggshell supplies approximately 80% of the calcium found in the hatchling chick. The mobilization of eggshell calcium into the developing embryo involves the transepithelial transport of large amounts of calcium in a development-specific manner. The cells responsible for the transport of eggshell calcium into the embryonic circulation are the ectodermal cells of the chorioallantoic ...

Angiogenesis that plays important roles in a variety of physiological processes is strictly delimited and finely tuned by a balance of pro-angiogenic and anti-angiogenic factors. Angiogenesis is essential for viability, growth, invasion and metastasis of tumors. The chorioallantoic membrane model is considered to be a valuable method for investigation of antiangiogenic effects of drugs and othe...