Approximately 240 million people worldwide are chronically infected with hepatitis B virus (HBV), which represents a significant challenge to public health. The current goal in treating chronic HBV infection is to block progression of HBV-related liver injury and inflammation to end-stage liver diseases, including cirrhosis and hepatocellular carcinoma, because we are unable to eliminate chroni...

BACKGROUND Acute hepatitis A virus (HAV) infection can cause severe hepatitis especially in patients with underlying chronic liver disease. In patients with pre-existing chronic hepatitis B (HBV) acute HAV infection can suppress HBV replication. The exact mechanism of HBV suppression during acute HAV infection is still a subject of debate. One mechanism may be the production of HAV infection-in...

Hepatitis D, also referred to as hepatitis D virus, or delta virus (HDV) is considered be a subviral satellite because it can propagate only in the presence of B (HBV) (WHO, 2020). There are uncertainties about epidemic patterns HDV infection and its contribution burden liver disease. defective that completes life cycle with (HBV). The HBV super-infection has been one most severe forms chronic ...

background: to determine the possible sources for the transmission of hepatitis b virus (hbv) infection to children in babol, north of iran.methods: forty-five boys and 35 girls with the mean age of 9.2±5.1 years were evaluated from 1993 to 2004. hepatitis b viral markers in all the family members were assessed. the risk factors for other sources were also determined.results: sixty-five (81.3%)...

abstract   background: hepatitis b virus infection is an important cause of liver morbidity and mortality worldwide. hdv changes the natural course of hbv. the prevalence of hdv infection wasn’t determined in the various groups of hbv infection (carriers, acute hepatitis, chronic hepatitis, cirrhosis and hcc) in iran. we aimed to research the prevalence of hepatitis d virus infection in various...

a hepatitis b virus (hbv) infection is a global public health problem. in endemic areas, hbv infection occurs mainly during infancy and early childhood, with mother to child transmission (mtct) accounting for approximately half of the transmission routes of chronic hbv infections. prevention of mtct is an essential step in reducing the global burden of chronic hbv. natal transmission accounts f...

Hepatitis B virus (HBV) infection is a major cause of chronic liver diseases that may progress to liver cirrhosis and hepatocellular carcinoma. Host immune responses are important factors that determine whether HBV infection is cleared or persists. After infection, viral replication occurs inside hepatocytes, and the secretion of infectious virions can take place at high rates for decades. Cons...

background immune cells and molecules play a vital role in initiating, maintaining, and regulating immunological homeostasis and inflammation in many pathological and physiological processes; however, the changes on expressions and functions of these cells and molecules in hepatitis b virus (hbv) infection has not been elucidated well. conclusions cxcr3-associated chemokines might contribute to...

Abstract An estimated 296 million people worldwide suffer from chronic hepatitis B virus (HBV) infection, with 1.5 new infections occurring each year despite the availability of an effective vaccine. Chronic HBV infection persists in a dysfunctional immune environment, manifested by ineffective T cell response to virus. Patient HBV-specific CD8 +T cells have diminished proliferative capacity an...

Hepatitis B virus (HBV) covalently closed circular (CCC) DNA is the source of HBV transcripts and persistence in chronically infected patients. The novel aspect of this study was to determine the effect of RNA interference (RNAi) on HBV CCC DNA when administered prior to establishment of HBV replication or during chronic HBV infection. HBV replication was initiated in HepG2 cells by transductio...