results liver function tests in the healthy blood donors were within the normal range. the incidence rates of senv-d and senv-h in the 184 total blood donors were 10 (5.4%) (95% confidence interval (ci): 2.1% - 9.0%) and 32 (17.4%) cases (95% ci: 12.0% - 23.0%), respectively. senv-h/d co-infection occurred in 2 (1.1%) patients. the sera of 8/184 (4.3%) were positive for anti-hbc antibody but ne...

conclusions genotype d was the main genotype detected in romanian patients with chronic hbv infection. genotype d presented both bcp and pc mutations more frequently. results we detected two hbv genotypes; a (8.1%) and d (60.5%), and a mixture of genotypes a and d (31.4%) (p < 0.001). basal core promoter (bcp) a1762t/g1764a and precore (pc) g1896a mutations were detected in these romanian patie...

chronic hepatitis c might lead to several immunological dysfunctions. studies have shown a positive association between hepatitis c virus (hcv) infection and psoriasis. these results suggest that the infection may be one of the triggering factors for the development or exacerbation of psoriasis. here, we present a case of chronic hcv infection with psoriasis who developed exacerbation of skin l...

800x600 hepatitis b virus (hbv) infection is the main cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma (hcc). several factors such as serum hbv dna level, genotype and specific viral mutations have been clarified to determine disease progression of chronic hepatitis b. among these, mutations can also occur in chronic hbv patients with antiviral treatment such as lamivudine the...

Chronic hepatitis B is still a major public health issue despite the successful prophylactic vaccination attempts. Chronicity of hepatitis B virus(HBV) is mainly due to its ability to debilitate host's immune system. Therefore, major measures have been taken to stop this process and help patients with chronic hepatitis B infection recover from their illness. While satisfactory results have been...

Background and Aims: chronic HBV infection is one of the most common viral infections in worldwide which many factors such as genetic factors are involved in pathogenesis of disease. Gamma interferon (IFN-&gamma;) and its receptor (INFGR) play a critical role in the immune response to HBV infection. Single nucleotide polymorphisms (SNPs) are effective on level of gene expression, The aim of thi...

results the tlr3 protein in the ach group tended toward reduction although the p value of the comparison between the ach group and hd group was not statistically significant. the tlr3 levels in the hcc, ac, and cir groups were higher than those in the hd and ach groups. tlr3 was not interrelated with all costimulation proteins in the dcs and t cells in all five groups. no group presented any in...

background and aims: viral hepatitis is a global health problem with a high mortality rate. recently, a new flavi-like virus, provisionally named hepatitis g virus (hgv), has been described. hgv does not induce an immune response that is consistently detectable by using recombinant proteins from prokaryotic expression, therefore studies have been conducted by using polymerase chain reaction (pc...

abstract background: hepatitis b virus (hbv) infection in patients who lack detectable hepatitis b surface antigen (hbsag) is called occult hepatitis b infection. such infections have been frequently identified in patients with chronic hepatitis cliver disease, but their prevalence is not known. methods: 207 patients with chronic hepatitis c who were hcv -rna and antihcv positive were studied f...

background: there are two forms of itp: acute and chronic. the chronic form is defined by persistent thrombocytopenia for more than 12 months and mostly occurs among young women. the aim of the present study was to evaluate the clinical variables in adult patients with chronic itp in west iran. patients and methods: between of 2007 and 2014, ninety adult patients with chronic itp referred to ou...