background: different measures of mortality and morbidity statistics is a good tool in determining the health status of a community،the health network development and application of methods of prevention and treatment. basis of mortality data is the death certificate and the most important index in death certificate is accuracy of death causes with who standards and death causes codes in icd10....

Cancer results if regulatory mechanisms of cell birth and death are disrupted. Colorectal tumorigenesis is initiated by somatic or inherited mutations in the APC tumor suppressor gene pathway. Several additional genetic hits in other tumor suppressor genes and oncogenes drive the progression from polyps to malignant, invasive cancer. The majority of colorectal cancers present chromosomal instab...

OBJECTIVE To determine the clinicopathologic and immunohistochemical predictors of the persistence/recurrence of cervical intraepithelial neoplasia (CIN) after cervical conization. METHODS Medical records of 502 patients who received cervical conization treatment of CIN between 2005 and 2012 were reviewed. The clinicopathologic parameters were analyzed using Cox hazard regression. Fifty patie...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background: definitions of chronic kidney disease (ckd) in many catheterization laboratories have relied on the serum creatinine (scr) rather than glomerular filtration rate (gfr). regarding that ckd is the primary predisposing factor for contrast induced nephropathy (cin), we compared the sensitivity of calculated gfr by ...

Pleiotropic pro-inflammatory cytokines, TNF-α and IFN-γ (TI), play important yet diverse roles in cell survival, proliferation, and death. Recent evidence highlights FAT10 as a downstream molecule in the pathway of inflammation-induced tumorigenesis through mediating the effect of cytokines in causing numerical CIN and protecting cells from cytokines-induced cell death. cDNA microarray analysis...

Pleiotropic pro-inflammatory cytokines, TNF-α and IFN-γ (TI), play important yet diverse roles in cell survival, proliferation, and death. Recent evidence highlights FAT10 as a downstream molecule in the pathway of inflammation-induced tumorigenesis through mediating the effect of cytokines in causing numerical CIN and protecting cells from cytokines-induced cell death. cDNA microarray analysis...

We performed a retrospective cohort study of 3530 women treated for cervical intraepithelial neoplasia (CIN) in Helsinki University Central Hospital, Finland, to investigate whether CIN treatment itself affects pregnancy incidence and outcome. We estimated the incidence of live births, miscarriages, extrauterine pregnancies, molar pregnancies, and termination of pregnancies (TOPs) before and af...

BACKGROUND Few studies have investigated the safe limits of contrast to prevent contrast-induced nephropathy (CIN) based on hydration data. We aimed to investigate the relative safe maximum contrast volume adjusted for hydration volume in a population with a relatively low risk of CIN. METHODS AND RESULTS The ratios of contrast volume-to-creatinine clearance (V/CrCl) and hydration volume to b...

Introduction: Recent research has reported the cytotoxic potential of hydrazones against various strains cancer cells. Aim: To evaluate anticancer activity in vitro and pharmacokinetic profile six synthesized hydrazonic compounds, identified as vanillin 1-phthalazinylhydrazone (VAN-1); 2,4-dinitrophenylhydrazone (VAN-2); phenylhydrazone cinnamaldehyde (CIN-1); isonicotinoyl hydrazone (CIN-2); 1...