Cinnamaldehyde, of the genius Cinnamomum, is a major constituent of the bark of the cinnamon tree and possesses broad-spectrum antimicrobial activity. In this study, we used best multiple linear regression (BMLR) to develop quantitative structure activity relationship (QSAR) models for cinnamaldehyde derivatives against wood-decaying fungi Trametes versicolor and Gloeophyllun trabeum. Based on ...

BACKGROUND AND PURPOSE Transient receptor potential ankyrin-1 (TRPA1) activation is known to mediate neurogenic vasodilatation. We investigated the mechanisms involved in TRPA1-mediated peripheral vasodilatation in vivo using the TRPA1 agonist cinnamaldehyde. EXPERIMENTAL APPROACH Changes in vascular ear blood flow were measured in anaesthetized mice using laser Doppler flowmetry. KEY RESUL...

Reversible protein glutathionylation is an important posttranslational modification that provides protection against oxidation. In endothelial cells (ECs), cinnamaldehyde is an electrophilic compound that can increase the intracellular glutathione (GSH) levels or reactive oxygen species (ROS) production depending on the treatment duration. ECs treated with GSH and H(2)O(2) show increased sulfhy...

Natural plant-derived antimicrobial nanocoatings have been synthesized by mixing brewed tea with cinnamaldehyde oil. Concurrent addition of copper or silver salts produces hybrid tea-cinnamaldehyde-copper tea-cinnamaldehyde-silver nanocoatings, respectively. Tea-cinnamaldehyde, tea-cinnamaldehyde-copper, and coatings are all found to display strong antibacterial efficacy against both Gram-negat...

The question addressed was whether the essential oil components, carvacrol and cinnamaldehyde, would have an interactive effect with regard to growth performance. One-day old female broiler chickens were subjected to one of 5 dietary treatments for 21 days: a base diet as a negative control, the base diet with 1% Carboxymethyl cellulose (CMC), the CMC diet with 200 ppm carvacrol, the CMC diet w...

OBJECTIVES To investigate the effect of cinnamaldehyde and eugenol on the telomere-dependent senescence of stem cells. In addition, to search the probable targets of mentioned phytochemicals between human telomere interacting proteins (TIPs) using in silico studies. MATERIALS AND METHODS Human adipose derived stem cells (hASCs) were studied under treatments with 2.5 µM/ml cinnamaldehyde, 0.1 ...

Objective: The aim of this study was to estimate the cheminformatics and qualitative structure-activity relationship (QSAR) of cinnamaldehyde and eugenol. The effects of cinnamaldehyde and eugenol on the viability, doubling time and adipogenic or osteogenic differentiations of human adipose-derived mesenchymal stem cells (hASCs) were also investigated.  Materials and Methods: QSAR and toxicity ...

Citation: Wang Y, Feng K, Yang H, Zhang Z, Yuan Y and Yue T (2018) Effect of Cinnamaldehyde and Citral Combination on Transcriptional Profile, Growth, Oxidative Damage and Patulin Biosynthesis of Penicillium expansum. Front. Microbiol. 9:597. doi: 10.3389/fmicb.2018.00597 Effect of Cinnamaldehyde and Citral Combination on Transcriptional Profile, Growth, Oxidative Damage and Patulin Biosynthesi...

Cinnamaldehyde, the bioactive component of the spice cinnamon, and its derivatives have been shown to possess anti-cancer activity against various cancer cell lines. However, its hydrophobic nature invites attention for efficient drug delivery systems that would enhance the bioavailability of cinnamaldehyde without affecting its bioactivity. Here, we report the synthesis of stable aqueous suspe...