Intervention in the molecular interactions that lead to an immune response is possible at various stages of Ag recognition and T cell activation. Perturbation of the interaction of the TCR with the MHC/peptide ligand complex is one approach that has shown promise for autoimmunity and graft rejection in blocking T cell-activated responses. In this study, we investigated the effect of altering th...

Dendritic cells (DC) are thought to initiate Ab synthesis by activation of T cells, which then provide cytokine and cell-bound "help" to B cells. Here, we provide evidence that DC can capture and retain unprocessed Ag in vitro and in vivo, and can transfer this Ag to naive B cells to initiate a specific Ab response. The response is skewed with 4- to 13-fold higher titers of IgG than IgM, and th...

Background Allospecific anti-HLA antibodies (Abs) are associated with rejection of solid organ grafts. The 2 main kits to detect anti-HLA Ab in patient serum are commercialized by Immucor and One Lambda/ThermoFisher. We sought to compare the performance of both platforms. Methods Background-adjusted mean fluorescence intensity (MFI) values were used from both platforms to compare sera collect...

A new class AB differential stage that operates with a single supply voltage of less than two transistor threshold voltages is introduced. This circuit has utilization in high slew rate one stage op-amps, two stage op-amps with class AB input and output stages and linear transconductors. The circuit was verified with simulations and experimentally. It it is shown to have lower voltage supply re...

A novel class-AB transconductance amplifier, suitable for the input stage of high slew rate CMOS operational amplifier is proposed. The proposed class-AB transconductor is realized from a differential pair of mixed translinear common-drain push-pull circuit. A high speed operational amplifier employing the proposed input stage and a complementary common –source high gain stage is presented. HSP...

we prove that the class of profinite groups $g$ that have a factorization $g=ab$‎ ‎with $a$ and $b$ abelian closed subgroups‎, ‎is closed under taking inverse limits‎ ‎of surjective inverse systems‎. ‎this is a generalization of a recent result by k. h. hofmann and f. g. russo‎. ‎as an application we reprove their generalization of iwasawa's structure theorem for‎ ‎quasihamiltonian pro-$p$...

One common design for routing protocols in mobile ad hoc networks is to use positioning information. We combine the class of randomized position-based routing strategies called AB (Above-Below) algorithms with face routing to form AB:Face2:AB routing algorithms, a new class of hybrid routing algorithms in mobile ad hoc networks. Our experiments on unit disk graphs, and their associated Yao sub-...

Some MHC class II genes provide dominant resistance to certain autoimmune diseases via mechanisms that remain unclear. We have shown that thymocytes bearing a highly diabetogenic, I-Ag7-restricted beta-cell-reactive TCR (4.1-TCR) undergo negative selection in diabetes-resistant H-2g7/x mice by engaging several different antidiabetogenic MHC class II molecules on thymic (but not peripheral) hemo...