In the title compound, C(7)H(6)ClN(3)O(4)S(2)·3C(5)H(5)N, (systematic name: 6-chloro-2H-1,2,4-benzothia-diazine-7-sulfonamide 1,1-dioxide pyridine tris-olvate), chloro-thia-zide forms a 1:3 solvate with pyridine. The crystal structure is stabilized by strong inter-molecular N-H⋯N hydrogen bonds.

Topicality. Сlemastine fumarate (tavegil)-1-methyl-2 [2-α-methyl-p-chlorobenzhydryloxy)-ethyl]-pyrrolidine is the first generation H1-histamine receptor blocker. selectively inhibits histamine H1 receptors and reduces capillary permeability. The drug has a pronounced anti-allergic antipruritic effect. Clemastine prevents development of vasodilation smooth muscle contraction induced by histamine...

The title compound, [MgBr2(C4H8O)4] (1a), forms twinned four-component monoclinic crystals as a new polymorph, space group P21/n with Z′ = 2, in addition to the already known tetragonal polymorph (1b). Although the molecular parameters in the two polymorphs match very well, the packing patterns are significantly different. Furthermore, the correct constitution of the mixed halide bromo-chloro-t...

BACKGROUND Angiotensin II receptor antagonists have been proposed as a replacement therapy after the occurrence of either an angiotensin converting enzyme (ACE) inhibitor-induced angioedema or cough. However, recent studies indicate that angioedema is associated with elevated bradykinin levels in a small fraction of patients treated with angiotensin-II-receptor blockers, suggesting a common pat...

It has been reported that some of H1 receptor antagonists have important effects on cardiovascular system. Terfenadine as a non-sedative H1 receptor antagonist has an arrhythmogenic activity. In this study we have shown the effects of four antihistamine drugs: terfenadine, loratadine, clemastine and diphenhydramine, on the rate and contractions of isolated rat atria. Terfenadine (1-10 μM) cause...

Nimesulide, a COX-2 selective drug, possesses anti-inflammatory and analgesic properties. Moreover, it has low gastrointestinal and renal toxicity. This paper presents industrially viable, new and improved synthesis of nimesulide starting from o-chloro nitrobenzene. The reaction with triphenyl phosphate yields 2-phenoxy nitrobenzene (90%) followed by reduction and mesylation and finally selecti...

It has been reported that some of H1 receptor antagonists have important effects on cardiovascular system. Terfenadine as a non-sedative H1 receptor antagonist has an arrhythmogenic activity. In this study we have shown the effects of four antihistamine drugs: terfenadine, loratadine, clemastine and diphenhydramine, on the rate and contractions of isolated rat atria. Terfenadine (1-10 µM) cause...

Tracheal smooth muscle obtained from ovalbumin-sensitized guinea pigs contracted with micromolar concentrations of tartrazine and indomethacin. The contractions were slightly reduced by clemastine, but were completely blocked by the SRS-A antagonist FPL 55712. Arylsulfatase B, which is an enzyme that inactivates SRS-A, also abolished the contractions induced by tartrazine. Contractions induced ...