نتایج جستجو برای: clinically isolated syndrome

تعداد نتایج: 1033495  

Journal: :Multiple sclerosis 2010
A Chan B F Decard C Franke V Grummel D Zhou V Schottstedt K V Toyka B Hemmer R Gold

BACKGROUND The proposed predictive value of serum anti-myelin antibodies for the development of multiple sclerosis after a first clinically isolated syndrome was recently challenged. OBJECTIVE To investigate myelin autoantibodies before first disease manifestation using different detection methods. METHODS Patients with multiple sclerosis who had donated blood at a time prior to development...

Journal: :AJNR. American journal of neuroradiology 2015
M Varosanec T Uher D Horakova J Hagemeier N Bergsland M Tyblova Z Seidl M Vaneckova J Krasensky M G Dwyer E Havrdova R Zivadinov

BACKGROUND AND PURPOSE The relationship between lesion formation and brain atrophy development in the early phase of multiple sclerosis is unclear. We investigated the association between new lesion accumulation and brain atrophy progression in patients with clinically isolated syndrome over 48 months. MATERIALS AND METHODS Patients with clinically isolated syndrome (n = 210) were evaluated w...

Journal: :AJNR. American journal of neuroradiology 2015
D Pareto J Sastre-Garriga C Auger Y Vives-Gilabert J Delgado M Tintoré X Montalban A Rovira

BACKGROUND AND PURPOSE The role of juxtacortical lesions in brain volume loss in multiple sclerosis has not been fully clarified. The aim of this study was to explore the role of juxtacortical lesions on cortical atrophy and to investigate whether the presence of juxtacortical lesions is related to local cortical thinning in the early stages of MS. MATERIALS AND METHODS A total of 131 patient...

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