BACKGROUND Oral lichen planus (OLP) is a chronic inflammatory disease that can be painful, especially in the atrophic and erosive forms. Several drugs have been used with varying results, but most treatments are empirical, and do not have adequate control groups or correct study designs. OBJECTIVES To compare the effectiveness of clobetasol and ciclosporin in the topical management of OLP and...

Over several decades, topical corticosteroids (TCs) have been used in the treatment of various dermatoses such as psoriasis, contact dermatitis, and eczema, among others. The TCs act by reducing inflammation irritation after application. therapeutic effect is bestowed through their diverse biologic properties anti-inflammatory, antiproliferative, vasoconstrictive, antimitotic activity, its role...

History A 74-year-old man presented with a 10-year history of itching skin eruption on his right forearm. It was treated with topical 0.05% clobetasol propionate cream prescribed by private practitioner. There was no photosensitivity or polyarthralgia. He did not have any constitutional symptoms. His past health was good. There was no history of pulmonary tuberculosis. He is allergic to penicil...

INTRODUCTION Several therapeutic options are available for the treatment of vitiligo; among these phototherapy and topical steroids are the most widely documented. A topical formulation of 0.05% clobetasol propionate foam (CPF) has been introduced in the market, but no data are available about the efficacy and tolerability of this new formulation in the treatment of vitiligo. The aim of this st...

A woman aged 23 years, with no past medical history of interest, was seen for the appearance a week earlier of pruritic skin lesions in the area of a tattoo created on the dorsum of her right foot 6 months earlier (Fig. 1). The patient denied taking any new medication or applying any topical products. There were no lesions on the rest of her skin or mucosas or lesions of the skin appendages. De...

Study sample The sample size was not determined in the planning phase of the study, and power calculations were not performed retrospectively. Initially, 7 women and 25 men (mean age 49 years) were enrolled in the study, all being residents of the San Francisco Bay area. Three patients were excluded and a justification for their exclusion was provided. The number of patients allocated to the tw...

OBJECTIVE We sought to analyze the results of topical treatment with a mouthwash of 0.05% clobetasol in aqueous solution in 30 patients with severe oral erosive lesions. STUDY DESIGN Over a 48-week period, we evaluated the evolution of pain, ulcerations, atrophy, and interference of the disease in the patient's daily life, classifying the response as complete (100% remission/recovery), excell...