نتایج جستجو برای: clustered damage
تعداد نتایج: 255021 فیلتر نتایج به سال:
Clustered damages are formed in DNA by ionising radiation and radiomimetic anticancer agents and are thought to be biologically severe. 7,8-dihydro-8-oxoguanine (8-oxoG), a major DNA damage resulting from oxidative attack, is highly mutagenic leading to a high level of G.C-->T.A transversions if not previously excised by OGG1 DNA glycosylase/AP lyase proteins in eukaryotes. However, 8-oxoG with...
Heavy particle irradiation produces complex DNA double strand breaks (DSBs) which can arise from primary ionisation events within the particle trajectory. Additionally, secondary electrons, termed delta-electrons, which have a range of distributions can create low linear energy transfer (LET) damage within but also distant from the track. DNA damage by delta-electrons distant from the track has...
It has been postulated that ionizing radiation produces a unique form of cellular DNA damage called "clustered damages" or "multiply damaged sites". Here, we show that clustered DNA damages are indeed formed in Escherichia coli by ionizing radiation and are converted to lethal double-strand breaks during attempted base-excision repair. In wild-type cells possessing the oxidative DNA glycosylase...
Three-dimensional finite element (FE) simulations of the deformation and damage evolution of SiC particle reinforced Al composites are carried out for different microstructures of the composites. A program for the automatic generation and the design of FE meshes for different 3D microstructures of composites is developed. Numerical testing of composites with random, regular, clustered and gradi...
The purpose of this study was to construct an organizational pathology scale and to investigate organizational damage in food industry companies based on the three-branch model. This research is applied study, in terms of its purpose and in terms of research method, it is a mixed type. The statistical population of this study is all employees of Amol Industrial City Food Industries Company. Th...
With clustered event time data, interest most often lies in marginal features such as quantiles or probabilities from the marginal event time distribution or covariate effects on marginal hazard functions. Copula models offer a convenient framework for modeling. We present methods of estimating the baseline marginal distributions, covariate effects, and association parameters for clustered curr...
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