We report In and Co nuclear magnetic resonance ~NMR! measurements in the heavy fermion superconductor CeCoIn5 above and below Tc . The hyperfine couplings of the In and Co are anisotropic and exhibit dramatic changes below 50 K due to changes in the crystal field level populations of the Ce ions, suggesting localized f electrons. Below Tc the spin susceptibility is suppressed, indicating single...

Link puzzles involve finding paths or a cycle in a grid that satisfy given local and global properties. This paper proposes algorithms that enumerate solutions and instances of two link puzzles, Slitherlink and Numberlink, by zero-suppressed binary decision diagrams (ZDDs). A ZDD is a compact data structure for a family of sets provided with a rich family of set operations, by which, for exampl...

(Abstract) We present an algorithm to compress hypergraphs into the data structure ZDDs and analyze the computational complexity. Since a ZDD provides an approach to solve large-scale problems that are difficult to compute in a reasonable amount of time and space, it is important to compress hypergraphs efficiently. Our algorithm uses multikey Quicksort given by Bentley and Sedgewick. By conduc...

Specific antibody production is an important issue in crossover pharmacokinetic (PK) studies of protein-based formulations. We recently reported that intravenous co-administration of tacrolimus with multiple human interferon-alpha (h-IFN) administrations successfully suppressed the production of anti-h-IFN antibodies in rats. Since crossover PK studies are preferentially carried out using large...

The co-infection of porcine reproductive respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) is quite common in clinical settings and no effective treatment to the co-infection is available. In this study, we established the porcine alveolar macrophages (PAM) cells model co-infected with PRRSV/PCV2 with modification in vitro, and investigated the antiviral activity of Matrin...

Synthetic (co)polymers or (co)oligomers with two (or more) repeating groups show not only molar mass distribution, but also composition and sequence distribution of the individual repeat units. To characterize such two- (or more-) dimensional distribution, liquid chromatography under "critical conditions" has been suggested, where the separation according to one type of repeating units is suppr...

introduction : tardive dyskinesia is one of the major side effects of long-term neuroleptic treatment. increased reactive oxygen species and oxidative stress has been proposed as possible etiopathologic mechanisms. ginkgo biloba extract (egb) is a natural antioxidant. we investigated the effects of ginkgo biloba extract on neuroleptic-induced orofacial dyskinesia in rats, a potential animal mod...

in induction of systemic and mucosal immunity, particulate antigens are more effective than soluble antigens possibly because they are more efficiently endocytosed by mucosal-associated lymphoid tissue (malt) m cells. in this study, we determined the systemic and mucosal immune responses in rabbits following intranasal immunization of tetanus toxoid tt and cpg-odn encapsulated within plga nanos...

Endogenous carbon monoxide (CO) exerts anti-inflammatory effects. Tristetraprolin (TTP) is known to destabilize pro-inflammatory transcripts. Here we found that exogenous CO enhanced the decay of TNF-α mRNA and suppressed TNF-α expression in LPS-activated macrophages from wild-type (WT) mice. However, TTP deficiency abrogated the effects of exogenous CO. While CO treatment prior to DSS administ...