The interest in the synthesis of metallic complexes of different drugs to make them moreefficient in biological environment of the human body is seen for the last few decades. Widerange of metal complexes are already used in clinical practice which encourages additionalresearch for innovating new metal based drugs, such as metal-mediated antibiotics, antiparasitic,antiviral, antibacterial, and ...

Male and female Sprague-Dawley rats were fed purified diets in which the carbohydrate component was either starch or refined sugar (sucrose). The addition to these diets of the ash prepared by the incineration of unrefined muscovado sugar prevented the deficiencies of Factor R seen in the offspring when the diets were not supplemented with ash. Analysis by neutron activation showed that the ash...

The influence of zinc, iron, cobalt, and manganese on submerged cultures of Fusarium moniliforme NRRL 13616 was assessed by measuring dry weight accumulation, fusarin C biosynthesis, and ammonia assimilation. Shake flask cultures were grown in a nitrogen-limited defined medium supplemented with various combinations of metal ions according to partial-factorial experimental designs. Zinc (26 to 3...

The synthesis of (diarylmethyl)sulfonamides and related compounds by a new manganese-mediated, cobalt-catalyzed three-component reaction between sulfonamides, carbonyl compounds and organic bromides is described. This organometallic Mannich-like process allows the formation of the coupling products within minutes at room temperature. A possible mechanism, emphasizing the crucial role of mangane...

A low-concentration cobalt (∼6 at%) and manganese (∼3 at%) bimetallic oxide catalyst supported on ceria nanorods (CoMnOx/CeO2), as well as its related single metal oxide counterparts (CoOx/CeO2 and MnOx/CeO2) was synthesized via a deposition-precipitation approach. The fresh samples after air-calcination at 400 °C were tested under the reaction conditions of CO oxidation, and showed the followi...

T HE essentiality of cobalt in the diet of sheep has been proved by Underwood and Filmer (I93~), Marston et al. (I938), Bowstead and Sackville (i939), Bowstead et el. (I94z), Pope et al. (1947), and by Keener et al. (I948). Numerous workers in this country and abroad also have identified cobalt deficiency m cattle. Little progress appears to have been made, however, in determining the function ...

OBJECTIVE The aim was to examine the relation between environmental and biological (blood and urine) indices of exposure to different chemical forms of cobalt. METHODS A cross sectional study was undertaken in workers exposed to cobalt metal, oxides, and salts in a refinery and to a mixture of cobalt and tungsten carbide in a hard metal producing plant. RESULTS AND CONCLUSION Although biolo...

Cobalt is a well-established inducer of hypoxia-like responses, which can cause gene modulation at the hypoxia inducible factor pathway to induce erythropoietin transcription. Cobalt salts are orally active, inexpensive, and easily accessible. It is an attractive blood doping agent for enhancing aerobic performance. Indeed, recent intelligence and investigations have confirmed cobalt was being ...

In the presence of Na(+) ions, the reaction of the ligand 2-hydroxy-1,3-bis-(3-oxo-3-(2-hydroxyphenyl)-propionyl)-benzene, H5L4, with M(AcO)2 salts (M = Mn, Co) gathers the conditions for the assembly of coordination complexes (NBu4)3[M2Na2(H2L4)3] (M = Mn(II) 1 and Co(II) 2), which exhibit a new paddle-wheel structure. The features of this new category of compounds are discussed as well as the...

Leflunomide, a type of disease modifying antirheumatic drug (DMARD) is a pyrimidine synthesis inhibitor which is chemically and pharmacologically very heterogeneous. It was selected as a bioactive ligand to react with hydrated salts of essential and trace metals to afford [M(Lef)4]X2, type complexes which were characterized by FT-IR, 1H-NMR and elemental analysis. In these reactions leflunomide...