1 Description LatFit allows the conversion of a protein’s full atom structure representation in Protein Data Bank (PDB) format into a coarse grained lattice model representation. This is done by 1. fitting the Cα-atoms to neighbored lattice positions for representation of the protein backbone. 2. If side chains are modelled, Cβ or the center of mass of the residues are fitted to neighbored posi...

In this paper we employ the Monotone Iteration Method and the Leray-Schauder Degree Theory to study an IR-parametrized system of elliptic equations. We obtain a curve dividing the plane into two regions. Depending on which region the parameter is, the system will or will not have solutions. This is an Ambrosetti-Prodi-type problem for a system of equations. 0. Introduction Let us consider a bou...

The problem of predicting the three-dimensional structure of a protein given its amino acid sequence is one of the most important open problems in bioinformatics. One of the carbon atoms in amino acids is the Cα-atom and the overall structure of a protein is often represented by a so-called Cα-trace. Here we present three different approaches for reconstruction of Cα-traces from predictable mea...

Calculations based on density functional methods are carried out to investigate the effects of a variety of substituents (NMe2, OMe, Me, F, H, Cl, CN, NO2) on the Mulliken charges (QM) for Cα and N atoms of N-(4-Substituted benzylidene)-1-phenylmethanamine oxide using Hammett’s MSP and Taft’s DSP equations. The MSP and DSP correlations give normal substituent effect at Cα and N atom sites. This...

In this paper we show that the best constrained degree reduction of a given Bézier curve f of degree from n to m with Cα−1-continuity at the boundary in L2-norm is equivalent to the best weighted Euclidean approximation of the vector of Bernstein–Bézier (BB) coefficients of f from the vector of degree raised BB coefficients of polynomials of degree m with Cα−1-continuity at the boundary.  2003...

This study evaluates a method to accurately, repeatably, and reliably extract camel zoo-metric data (linear tridimensional) from 2D digital images. Thirty zoometric measures, including linear tridimensional (perimeters girths) variables, were collected on-field with non-elastic measuring tape. A scaled reference was used measurement For girths perimeters, semimajor semiminor axes mathematically...

Exogenous apolipoprotein A-I (apoA-I) associates with ATP-binding cassette transporter A1 (ABCA1) on the cell surface of astrocytes like various peripheral cells and enhances the translocation of newly synthesized cholesterol from the endoplasmic reticulum/Golgi apparatus (ER/Golgi) to the cytosol. The cholesterol translocated to the cytosol is incorporated to cytosolic lipid-protein particles ...

Cyclic AMP/protein kinase A (cAMP/PKA) and glucocorticoids promote the death of many cell types, including cells of hematopoietic origin. In wild-type (WT) S49 T-lymphoma cells, signaling by cAMP and glucocorticoids converges on the induction of the proapoptotic B-cell lymphoma-family protein Bim to produce mitochondria-dependent apoptosis. Kin(-), a clonal variant of WT S49 cells, lacks PKA ca...

NMR chemical shift tensors (CSTs) in proteins, as well as their orientations, represent an important new restraint class for protein structure refinement and determination. Here, we present the first determination of both CST magnitudes and orientations for (13)Cα and (15)N (peptide backbone) groups in a protein, the β1 IgG binding domain of protein G from Streptococcus spp., GB1. Site-specific...