110 patients with thyroid nodules were examined by ultrasound during the period from April 1981 to June 1983. All patients had thyroid isotope scans which showed cold nodules. Subsequent surgery was performed in each case and histology of the lesions identified. Prior to the introduction of ultrasound the only useful preoperative diagnosis was made by thyroid scintiscanning." The present study ...

Thyroglobulin gene mutation is a rare cause of congenital hypothyroidism, but thyroglobulin gene mutations are thought to be associated with thyroid cancer development. A 21-year-old Japanese man treated with levothyroxine for congenital hypothyroidism had an enlarged thyroid gland with undetectable serum thyroglobulin despite elevated serum TSH level. The patient was diagnosed with thyroglobul...

A 44-year-old euthyroid woman had two palpable nodules in the thyroid gland. 123I thyroid scintigraphy showed a hot nodule in the right lobe and a cold one in the left lobe. Total thyroidectomy was performed, and histopathologic examination revealed that both tumors contained papillary carcinoma. Thus, hot nodules on a thyroid scintigram with 123I do not necessarily preclude malignancy.

In the evaluation of thyroid nodules the three major clinical concerns are malignancy, hyperfunction, and cosmetic effect. It is now well accepted that the isolated "cold" nodule is the clinical setting in which thyroid cancer most often occurs (1-2). The clinical problem most often inferred from the presence of a "hot" nodule is hyperfunction. However, the clinical course, and natural history ...

We aimed to investigate the diagnostic accuracy of ultrasound (US)-guided fine-needle aspirates (FNAs) obtained from 854 consecutive Danish patients with a scintigraphically cold thyroid nodule in a borderline iodine-deficient area. Clinical, sonographic, and pathological findings in patients with a cold thyroid nodule undergoing US-guided FNA were prospectively registered. 408 patients underwe...

There are over 11,000 new cases of thyroid cancer each year in the US. Females are more likely to have thyroid cancer than men by a ratio of 3:1, and it is more common in people who have been treated with radiation to the head, neck, or chest, most often for benign conditions (although radiation treatment for benign conditions is no longer carried out). Thyroid cancer can occur in any age group...

Objective. This was a comparative study between FNAC and thyroid scan used to diagnose the solitary thyroid nodule and histopathology was used as gold standard to compare the results of both modalities. We hypothesized that Fine needle aspiration cytology and thyroid scan diagnose solitary thyroid nodule (STN) as accurately as histopathology. Materials and Methods. This study comprised of 50 pa...

A 63-year-old woman presented with a history of hyperthyroidism symptoms over two years, referred for thyroid scintigraphy. In the hospital archives we have met her previous thyroid scintigraphy showing a hot nodule in the upper part of right thyroid lobe. However, her recent thyroid scintigraphy was showing only cold nodules but no hot nodule, giving an impression that she had some treatment t...

Secondary neoplasm of the thyroid mimicking a primary thyroid lesion is a rare finding, especially in an individual without a past history of malignancy. A case of squamous cell carcinoma metastatic to the thyroid (presenting as a solitary thyroid nodule), who had an unsuspected primary in the esophagus is described. Usually, multiple areas of the gland are involved in the secondary involvement...

AIM To evaluate the long-term efficacy of interstitial laser photocoagulation (ILP) in solitary benign thyroid nodules. DESIGN AND METHODS A total of 78 euthyroid outpatients (45 participating in randomized trials) with a benign solitary solid and scintigraphically cold thyroid nodule causing local discomfort were assigned to ILP. ILP (using one laser fiber) was performed under continuous ult...