The calcium-binding protein S100A4 is a central mediator of metastasis formation in colon cancer. S100A4 is a target gene of the Wnt/β-catenin pathway, which is constitutively active in the majority of colon cancers. In this study a high-throughput screen was performed to identify small-molecule compounds targeting the S100A4-promoter activity. In this screen calcimycin was identified as a tran...

The development of Colorectal cancer (CRC), the fourth most common cause of malignancy worldwide, is driven by the sequential accumulation of genetic changes. In the Western world, more than 80% of sporadic CRC cases arise from aberrant activation of the WNT-pathway, including mutations in the adenomatous polyposis coli (APC) tumor suppressor gene and CTNNB1 transcription factor, and followed b...

Inflammatory Bowel Disease (IBD) classified with Ulcerative Colitis (UC) and Crohn Dis‐ ease (CD) is an idiopathic, life-long, destructive chronic inflammatory disease in gastrointes‐ tinal tract [1] and probably multi-factorial disease caused by interplay of the external and internal environment. Little is known about the mechanism of pathogenesis of the disease but it has been reported that i...

The rationale of the present study is to formulate flurbiprofen colon targeted compression coated tablets using guar gum to improve the therapeutic efficacy by increasing drug levels in colon, and also to reduce the side effects in upper gastrointestinal tract. Direct compression method was used to prepare flurbiprofen core tablets, and they were compression coated with guar gum. Then the table...

Nanobiomaterials such as enveloped virus-like particles with specificity can serve a dual function of vaccination and drug delivery system. Here, we expressed colon carcinoma cell-targeting chimeric virus-like particles (VLPs) made using two capsid proteins, gag and M1 from influenza virus A/swine flu/Iowa/15/30/H1N1 in silkworms. These chimeric VLPs displayed a glycosylphosphatidylinositol-anc...

Metastasis of colon cancer cells increases the risk of colon cancer mortality. We have recently shown that American ginseng prevents colon cancer, and a Hexane extract of American Ginseng (HAG) has particularly potent anti-inflammatory and anti-cancer properties. Dysregulated microRNA (miR) expression has been observed in several disease conditions including colon cancer. Using global miR expre...

Abstract: Aim: The goal of this study was to develop colon-targeted nanoparticulate systems the anti-inflammatory agent Quercetin (QU) and evaluate formulation for various parameters that would allow active ingredient be released at a predetermined time location with better pharmaceutical therapeutic properties. Materials Methods: Quercetin-loaded chitosan nanoparticles were formulated purpose ...

Polysaccharide-based carriers have become attractive materials for the delivery of therapeutics targeting colon. Ferulated arabinoxylans (AX)—polysaccharides with gelling and antioxidant capacities that can be degraded by colonic microbiota—are ideal candidates use as oral drug systems [1]. Recently, AX-based microspheres demonstrated potential applications colon-targeted [2,3]. The non-cytotox...

the present study , was an attempt to develop galactosylated albumin nanoparticles of simvastatin for treatment of hypercholesterolemia. by developing the galactosylated nanoparticulated delivery the required action of drug at the target site at liver can be provided. the advantage of targeting helps to reduce the systemic side effects which may be occur due to the distribution of the drug to t...

The colon targeted drug delivery has a number of important implications in the field of pharmacotherapy. Oral colon targeted drug delivery systems have recently gained importance for delivering a variety of therapeutic agents for both local and systemic administration. Targeting of drugs to the colon via oral administration protect the drug from degradation or release in the stomach and small i...