PURPOSE OF REVIEW Epilepsy is a chronic disorder with several associated comorbidities requiring timely recognition and treatment. This article discusses aspects of cognitive impairment; psychiatric disorders including depression, anxiety, and psychosis; and health-related quality-of-life issues pertaining to patients with epilepsy. RECENT FINDINGS Cognitive problems in epilepsy may be presen...

Psoriasis is a chronic inflammatory disease which is a result of complex interactions between genetic, environmental, and immunological factors. Psoriasis is now accepted as a systemic disorder accompanied by comorbidities rather than simply a cutaneous disease. Psoriasis has been associated with a number of systemic diseases such as diabetes mellitus, obesity, hypertension, metabolic syndrome,...

Gout is a chronic disease in which excessively high levels of serum urate (hyperuricemia) result in tissue depositions of sodium urate crystals and intermittent inflammatory attacks. Patients who have gout frequently experience a range of comorbidities, which complicates management and affects long-term prognosis. We review some of the more important of these comorbidities and consider the exte...

1 Louise just came out of the doctor’s office, after having received a diagnosis of major depression. She feels relieved to know that she will finally be able to get help for her problems. On the other hand, she remains ambivalent about what she could have told the doctor and did not dare to talk about, like the aggression she experienced that continues to haunt her every day, her frequent alco...

Comorbidity refers to the presence of an additional co-existing ailment in a patient with a particular index disease. Migraine co-morbidities have been reported in various clinical and case control studies. Comorbidities impose a high socio-economic burden on society and compromise the quality of life in migraineurs. There are several factors which can complicate the investigation of co-morbidi...

The timely and well-structured presentation concerning the burden of comorbidities and functional and cognitive impairments in elderly patients with heart failure by Murad et al. (1) and the accompanying thought-provoking editorial by Shaffer and Maurer merit an additional point of concern regarding mortality. The comorbid statistical assessment of factors contributing to greater total mortalit...

Psoriasis is a common inflammatory skin condition, often associated with other diseases. Around 25 % of patients develop joint involvement in the form of psoriatic arthritis as well. Recent epidemiologic studies demonstrated an increased cardiovascular morbidity among psoriasis patients, which contributes to their reduced life expectancy. High prevalence of the metabolic syndrome as well as adv...

Psoriasis is a chronic inflammatory disease associated with several comorbidities. A few decades ago, it was considered an exclusive skin disease but today it is considered a multisystem disease. It is believed that 73% of psoriasis patients have at least one comorbidity. Studies have demonstrated the association of psoriasis with inflammatory bowel disease, uveitis, psychiatric disorders, meta...

Psoriasis is a chronic inflammatory, immune-mediated skin disease, which affects 2%-3% of the population worldwide. Chronic plaque psoriasis is frequently associated with metabolic diseases including diabetes, obesity, dyslipidemia, metabolic syndrome and nonalcoholic fatty liver disease. Although the causal relationship between metabolic comorbidities and psoriasis has not yet been completely ...

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Age and smoking are common risk factors for COPD and other illnesses, often leading COPD patients to demonstrate multiple coexisting comorbidities. COPD exacerbations and comorbidities contribute to the overall severity in individual patients. Clinical trials investigating the treatment of COPD...