After publication of this work [1], we noted that we inadvertently failed to include the complete list of all coau-thors. The full list of authors has now been added and the Authors' contributions and Competing interests section modified accordingly. Authors' contributions SJK prepared for the manuscript and study coordination; IPH prepared for building up the experimental environment and execu...

A resource-efficient approach to making inferences about the distributional properties of the failure times in a competing risks setting is presented. Efficiency is gained by observing recurrences of the compet- ing risks over a random monitoring period. The resulting model is called the recurrent competing risks model (RCRM) and is coupled with two repair strategies whenever the system fails. ...

The population-dispersal dynamics for predator-prey interactions and two competing species in a two patch environment are studied. It is assumed that both species (i.e., either predators and their prey, or the two competing species) are mobile and their dispersal between patches is directed to the higher fitness patch. It is proved that such dispersal, irrespectively of its speed, cannot destab...

Large-scale analyses of protein-protein interactions based on coarse-grain molecular docking simulations and binding site predictions resulting from evolutionary sequence analysis, are possible and realizable on hundreds of proteins with variate structures and interfaces. We demonstrated this on the 168 proteins of the Mintseris Benchmark 2.0. On the one hand, we evaluated the quality of the in...

Frequency-dependent selection reflects the interaction between different species as they battle for limited resources in their environment. In a stochastic evolutionary game the species relative fitnesses guides the evolutionary dynamics which fluctuate due to random drift. Dependence of species selection advantages on the environment introduces additional possibilities for the evolutionary dyn...

ion PIU-Environment Clock-Level Behavior PIU-Environment Clock-Level Structure PIU Clock Level 1_ Composition Environment Clock Level Figure 2.1: Example PIU Specification Hierarchy Using Clock-Level Composition. Figure 2.2 describes a competing approach where abstraction is performed within the subsystems themselves, before composition. The abstract PIU specification in this case describes the...

Product development is often performed by functionally and geographically distributed groups of people. In such an environment, there are many concerns that must be traded off against one another before a product can be brought to market. An example of this tradeoff is high performance versus low cost; a product with high performance generally costs more than a product with low performance. Whe...

Understanding and predicting the evolution of competing languages is a topic of high interest in a world with more than 6000 languages competing in a highly connected environment. We consider a reasonable mathematical model describing a situation of competition between two languages and analyse the effect of the speakers’ connectivity (i.e. social networks). Surprisingly, instead of homogenizin...