نتایج جستجو برای: complement blood
تعداد نتایج: 750829 فیلتر نتایج به سال:

 CADTH recommends that Ultomiris be reimbursed by public drug plans for the treatment of adult and pediatric patients at least 1 month age older with atypical hemolytic uremic syndrome (aHUS) to inhibit complement-mediated thrombotic microangiopathy (TMA), if certain conditions are met.
 should only covered treat adults children (aged or older) who: have aHUS, evidence ongoing progre...
The complement system is an important inflammatory mediator during procedures such as cardiopulmonary bypass and hemodialysis when blood is exposed to large areas of biomaterial surface. This contact between blood and the biomaterials of implants and extracorporeal circuits leads to an inflammatory response mediated by the complement system. The aim of this study was to assess the ability of a ...
Oncolytic viruses (OVs) have shown promising clinical activity when administered by direct intratumoral injection. However, natural barriers in the blood, including antibodies and complement, are likely to limit the ability to repeatedly administer OVs by the intravenous route. We demonstrate here that for a prototype of the clinical vaccinia virus based product Pexa-Vec, the neutralizing activ...
the sequestration of rat leukocytes and bone marrow cells by the lung vasculature was studied using an isolated perfused rat lung preparation. the passage of latex particles of 7.6 µm in diameter and non-hematopoietic cells through the lung blood vessels was also studied. leukocytes and bone marrow cells were reversibly sequestered from circulation, whereas, latex particles and non-hematopoieti...
Complement factor C3, the central protein of the complement system, was found to be phosphorylated both in EDTA- and heparin-anticoagulated whole blood and in coagulating blood. Complement S protein (vitronectin) was also found to be phosphorylated under these conditions. Further, purified C3 was found to be a phosphoprotein in vivo, containing 0.15 mol of alkali-labile phosphate/mol of protein...
The ability of complement in human menstrual blood and cervical mucus to kill Trichomonas vaginalis was compared with that of complement in serum, and 95 fresh trichomonal isolates obtained from vaginal wash material were evaluated for susceptibility to complement immediately after isolation. Only serum and menstrual blood with haemolytic activity produced total cytolysis of T vaginalis. The cy...
Background: The components of the classical complement pathway play an important role in the pathogenesis of systemic lupus erythematosus (SLE) and are reportedly useful biomarkers of disease activity. In this study, we evaluate disease activity, complement function (total hemolytic complement, CH50) and complement protein levels (C3, C4, C3d, C4d, SC5b-9), comparing the results of patients wit...
Background and objective: The development of cardiovascular diseases and mortality caused this study to evaluate the effect of 6 weeks of supplemental diet and aerobic exercise on plasma levels of CRP and fibrinogen in overweight men. Method: 32 non-athletic overweight men from Qom University with a mean age of 31 ± 1.38 years, and body mass index 31.19 ± 4.18 kg / m2, were randomly assigned to...
Full blood count and erythrocyte sedimentation rate, antistreptolysin titre, albumin/ globulin ratio, blood sugar estimation, gonococcal complement-fixation test, Wassermann and Treponema pallidum immobilization tests, Waaler-Rose latex-fixation test, Toxoplasma complement-fixation test, Tine test, histoplasmosis complement-fixation test. Urine and stool examination for parasites and bacteria. ...
BACKGROUND Intravenous (IV) iron preparations are widely used in the treatment of anemia in patients undergoing hemodialysis (HD). All IV iron preparations carry a risk of causing hypersensitivity reactions. However, the pathophysiological mechanism is poorly understood. We hypothesize that a relevant number of these reactions are mediated by complement activation, resulting in a pseudo-anaphyl...
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