Multicomponent reactions involving polyfunctional 4-amino-5-carboxamido-1,2,3-triazole and cyclic carbonyl-containing CH-acids were studied under conventional thermal heating, microwave and ultrasonic irradiation. The features of the reactions studied were discussed and the optimized procedures for the synthesis of final triazolopyrimidines were elaborated. In contrast to the similar MCRs of nu...

Multicomponent reactions (MCRs) are remarkable one-pot combinatorial synthetic tools involving at least three reactants whose nearly all atoms incorporated in the final product. The development of these high atom-efficient considerably raised level molecular complexity and diversity last decades. Nowadays, MCRs no longer confined to organic synthesis have seen their use extended polymer science...

BACKGROUND AND OBJECTIVES Multiple chromosome rearrangements (MCRs) are found in 5-10% of newly diagnosed patients with acute myeloid leukemia (AML) and 15-30% of patients with myelodysplastic syndromes (MDS). However, the initial causes of MCRs and the molecular mechanisms involved are largely unresolved. Nor are the karyotypic patterns well studied, mainly because of the difficulties of obtai...

This paper investigates prices of consumer electronics sold on the Web by both onlineonly retailers (Dotcoms) and the online branches of multi-channel retailers (MCRs). Surprisingly, we find that Dotcoms charge higher price than MCRs, a conclusion contradictory to the results of most of empirical studies. We also find that the electronics prices decreased over the period of study in general, dr...

In the recent past, the design and synthesis of peptide mimics (peptidomimetics) has received much attention. This because they have shown in many cases enhanced pharmacological properties over their natural peptide analogues. In particular, the incorporation of cyclic constructs into peptides is of high interest as they reduce the flexibility of the peptide enhancing often affinity for a certa...

the efficient and environmentally friendly method for the one-pot synthesis of polyhydroquinolines has been developed in the presence of cuo nanoparticles. the multi-component reactions of aldehydes, dimedone, ethyl acetoacetate andammonium acetate were carried out under solvent-free conditions to afford some polyhydroquinoline derivatives. this method provides several advantages including high...

cui nanoparticles as an expedient and recyclable catalyst for the synthesis of n-cyclohexyl-3-aryl-quinoxaline-2-amines in ethanol via a multi-component reaction are established. the products were separated from the catalyst simply by filtration. the catalyst could be recycled and reused for several times without noticeably decreasing the catalytic activity.

one of the most important goals in medicinal chemistry is the development of new techniques and new heterocyclic compounds with pharmaceutical activity. the present study aimed to use a method for the synthesis of some 1,2-dihydro-1-arylnaphtho [1,2-e] [1,3] oxazine-3-ones. the question this study tried to answer was this reaction can be performed in present of nano-fe2o3 as an acid catalyst an...

in this study, cui nanoparticles as an efficient catalyst was used for the synthesis of 14-phenyl-8h-dibenzo[a,i]xanthene-8,13(14h)-diones using aldehydes, 2-naphthol and 2-hydroxynaphthalene-1,4-dione in aqueous media. in this study, it was found that water was the most effective solvent compared to others. among several catalysts that were tested for this multi-component synthesis, cui nanopa...