Insulin is secreted in a pulsatile manner from multiple micro-organs called the islets of Langerhans. The amplitude and phase (shape) of insulin secretion are modulated by numerous factors including glucose. The role of phase modulation in glucose homeostasis is not well understood compared to the obvious contribution of amplitude modulation. In the present study, we measured Ca2+ oscillations ...

This article reports a method for controlling the chemical concentration in a localized region of a fluid using optoelectrofluidic mechanisms. Optoelectrofluidic fluorescence microscopy (OFM), in which an optoelectrofluidic device is integrated into a conventional fluorescence microscope, allows both modulation and detection of local chemical concentration in an easy and simple way. Here, we pr...

Doping is an effective way to modify the electronic property of two-dimensional (2D) materials and endow them with additional functionalities. However, wide-range control doping concentratio...

Modulating the electric potential on a conducting electrode is presented to generate an optical contrast for scattering microscopy that sensitive both surface charge and local topography. We dub this method Electric-Double-Layer-Modulation microscopy. numerically compute change in ion concentration origin of three experimentally relevant geometries: nanosphere, nanowire, nanohole. In absence pl...

The study was performed to determine the gestational age of preterm infants that requires amikacin therapeutic drug monitoring. A study was conducted in preterm infants on amikacin therapy with gestational age of 28 to 36 weeks. Therapeutic drug monitoring in preterm infants was performed based on their individual pharmacokinetics to avoid ototoxicity and nephrotoxicity. Its prerequisite, becau...