PURPOSE In Thailand, there has been no study determining the concomitant use of medications, known to potentially interact with warfarin, in patients receiving warfarin therapy. This paper examined the frequency of which specific interacting drugs were concomitantly used in warfarin users. METHODS We retrospectively examined the database of warfarin outpatient medical records from a regional ...

background: to date, studies on methadone overdose in adults have not been ‎reported in iran. hence, this study was performed to determine the frequency of ‎methadone overdose and its associated complications in baharloo hospital of tehran ‎between august 2011 and august 2012.‎ methods: this cross-sectional study was done on 390 cases. all patients with ‎methadone overdoses and positive urine s...

the aim of the present study was to evaluate the pattern of vancomycin administration in the hematology-oncology ward of nemazee hospital, shiraz, iran. study criteria were developed to assess the several parameters involved in vancomycin therapy. these parameters include the appropriateness of drug usage, dosage, duration of therapy, monitoring for toxicity and serum concentration monitoring. ...

Background Occult hepatitis B infection (OBI) is considered a risk factor for progression of liver disease in patients with hepatitis B virus (HBV) infection. This disease progression is reported to be more significant in those with concomitant HIV infection. We aimed to determine the prevalence rate of OBI in a sample of HIV-positive patients. Materials and Methods: Sixty-six HIV-infected pati...

poly-drug use refers to the use of two or more substances at the one time or repeatedly. it is common among both recreational and regular drug users across the world. poly-drug use is a great contributor to the global number of deaths related to drug overdose. in this case, the likelihood of drug overdose and its pertaining complications in an individual is higher especially when benzodiazepine...

Background Rolapitant, a long-acting neurokinin (NK)1 receptor antagonist (RA), has demonstrated efficacy in prevention of chemotherapy-induced nausea and vomiting in patients administered moderately or highly emetogenic chemotherapy. Unlike other NK1 RAs, rolapitant does not inhibit or induce cytochrome P450 (CYP) 3A4, but it does inhibit CYP2D6 and breast cancer resistance protein (BCRP). To ...

Use of concomitant medications with antipsychotic agents in the treatment of schizophrenia is common but lacks a clear scientific rationale. We evaluated concomitant medication usage during the first 6 months of the prospective, observational, European Schizophrenia Outpatient Health Outcomes (SOHO) study, examining its frequency, variation according to type of antipsychotic drug used, and impa...