OBJECTIVES To evaluate the role of P-glycoprotein (P-gp) and multidrug-resistant-protein 1 (MRP1) on raltegravir intracellular drug disposition in CD4+ T cells, investigate the effect of HIV-1 infection on P-gp expression and correlate HIV-1 viraemia with P-gp activity in primary CD4+ T cell subsets. METHODS The cellular accumulation ratio of [(3)H]raltegravir was quantified in CD4+ T cell li...

We study the stability of traveling waves of nonlinear Schrödinger equation with nonzero condition at infinity obtained via a constrained variational approach. Two important physical models are Gross-Pitaevskii (GP) equation and cubic-quintic equation. First, under a non-degeneracy condition we prove a sharp instability criterion for 3D traveling waves of (GP), which had been conjectured in the...

objective(s):transporters have an important role in pharmacokinetics of drugs. inhibition or induction of drug transporters activity can affect drug absorption, safety, and efficacy. p-glycoprotein (p-gp) is the most important membrane transporter that is responsible for active efflux of drugs. it is important to understand which drugs are substrates, inhibitors, or inducers of p-gp to minimize...

The accumulation of beta-amyloid [Aβ] within senile plaques [SP] is characteristic of these lesions in Alzheimer's disease. The accumulation of Aβ 42, in particular, in the superior temporal [ST] cortex may result from an inability of the blood brain barrier (BBB) to regulate the trans-endothelial transport and clearance of the amyloid. Lipoprotein receptor-related protein [LRP] and P-glycoprot...

Limited energy intake may result in the down-regulation of cellular defense mechanisms, or if maintained, result in trade-offs with other physiological systems. To examine this, juvenile rainbow trout (Oncorhynchus mykiss) were fed full-rations (1.17% body weight [BW]/day), half-rations (0.59% [BW]/day), or fasted for 9 weeks followed by refeeding at full-rations. BW and liver somatic index (LS...

p-glycoprotein (p-gp) is a trans-membrane drug efflux pump. several drugs are p-gp substrates. some drugs may affect the activity of p-gp by inhibiting its function, resulting in significant drug-drug interactions (ddis). it is critical to understand which drugs are inhibitors of p-gp so that adverse ddis can be minimized or avoided. this study investigated the effects of gliclazide, metformin,...

Objective(s): In the present study,a new series of 6-methoxy-2-arylquinoline analogues was designed and synthesized as P-glycoprotein (P-gp) inhibitors using quinine and flavones as the lead compounds. Materials and Methods: The cytotoxic activity of the synthesized compounds was evaluated against two human cancer cell lines including EPG85-257RDB, multidrug-resistant gastric carcinoma cells (P...

OBJECTIVES Clinical and immunological features of patients with clinical manifestations of the antiphospholipid syndrome (APS) with anti-beta2-glycoprotein-I antibodies (anti-beta2-GP-I) but without anticardiolipin antibodies (aCL) or any other autoimmune condition are not well documented. We sought to determine the clinical significance of positive anti-beta2-GP-I with negative aCL. METHODS ...