Background: Congenital hepatic fibrosis (CHF) is an autosomal hereditary disorder affecting the porto-biliary system. It is a rare hereditary disorder often presenting in childhood or adolescence with hepatomegaly, splenomegaly, and gastrointestinal bleeding. A timely diagnosis of organomegalies by sonography can prevent esophageal varices. Liver transplantation is now the only...

Congenital hepatic fibrosis is a rare cause of portal hypertension and esophageal varices in children. We report cases of siblings with biopsy proven congenital hepatic fibrosis and with atypical retinitis pigmentosa. They presented with repeated episodes of jaundice along with progressive decrease of vision in night. They had hepatosplenomegaly and portal hypertension with esophageal varices. ...

Congenital hepatic fibrosis is a relatively rare disease of children and young adults characterized by hard hepatomegaly, portal hypertension with relative preservation of liver function and underlying architecture, and frequent renal involvement. We experienced 3 cases of congenital hepatic fibrosis with Caroli's disease in 3 siblings, whose clinical manifestations were diverse, such as repeat...

conclusions non-invasive assessment of hepatic fibrosis could be done using the egy-score. egy-score could differentiate no or early fibrosis (stage f0-f2 metavir) from severe fibrosis or cirrhosis (stage f3 - f4 metavir) with 83.7% accuracy. results combined elevation of ca 19-9 and ca 125 with a summated value > 37 u/ml is predictive of severe hepatic fibrosis or cirrhosis (stage f3-f4 metavi...

hepatitis c virus (hcv) infection causes chronic hepatitis, which frequently leads to hepatic fibrosis and hepatocellular carcinoma (hcc). alanine aminotransferase (alt) is a biomarker of hepatocyte injury and is associated with the progression of hepatic fibrosis. advanced hepatic fibrosis also predisposes hcv carriers to a risk of hcc. in contrast, some cases with persistent hcv infection hav...

objective(s):to clarify the protective effects of cichorium glandulosum (cg) extracts on thioacetamide (taa)-induced rat hepatic fibrosis. materials and methods: the dry roots of cg were smashed and percolated with 95% ethanol, and the residual was prepared into petroleum ether extract (cg-v), ethyl acetate extract (cg-vi) and n-butyl alcohol extract (cg-vii). thirty-six wistar rats were random...

the influence of glycosaminoglycans (gag) on collagen fibrillogenesis in vitro was investigated. gag and collagen were isolated from the liver of rats treated with carbon tetrachloride at various time intervals (3-16 weeks). it was found that gag obtained from the fibrotic liver accelerated collagen fibril formation. this effect was more evident in a solution of type i collagen than type iii co...