this study was aimed to determine prevalence of vitamin d deficiency and rickets in children with cholestatic liver diseases. forty eight children with established cholestatic liver disease who referred to gastrointestinal clinic of children medical center (tehran, iran) between april 2010 and march 2011 were enrolled in a cross-sectional study. laboratory analysis including calcium, phosphate,...

The association of rickets or osteomalacia with a variety of renal tubular defects, probably congenital, has been called by many different names such as resistant rickets, Fanconi syndrome, and hyperchloraemic acidosis with nephrocalcinosis. They have been classified by I)ent (1952) into six main types according to the various combinations of recognisal)Ie defects of tubule function. The Fancon...

Syndromes of bone disease and deformities consequent to disorders of nutrition, bone and mineral metabolism constitute a serious national health problem. The studies on this subject are scanty. Data on nutritional bone disease are described and discussed. We had surveyed 337.68 million population residing in 0.39 million villages in 22 States of India during the period 1963 to 2005. Of the 4,11...

Rickets is a metabolic bone disease that develops as a result of inadequate mineralization of growing bone due to disruption of calcium, phosphorus and/or vitamin D metabolism. Nutritional rickets remains a significant child health problem in developing countries. In addition, several rare genetic causes of rickets have also been described, which can be divided into two groups. The first group ...

Rickets develops when growing bones fail to mineralize. In most cases, the diagnosis is established with a thorough history and physical examination and confirmed by laboratory evaluation. Nutritional rickets can be caused by inadequate intake of nutrients (vitamin D in particular); however, it is not uncommon in dark-skinned children who have limited sun exposure and in infants who are breastf...

Congenital Glucose Galactose malabsorption (CGGM) is a rare disorder with limited data from the Arab world. We report the first case of CGGM in Oman.B.S.A two years old female who presented with chronic osmotic diarrhea since birth with hypernatraemic dehydration. B.S was found to have Glucose Galactose Malabsorption based on clinical trial of ORS and elemental formula. Symptoms resolved on int...

Rickets is typically due to nutritional cause, namely vitamin D and calcium deficiency worldwide. When there suboptimal response conventional supplementation, alternative causes have be sought. We report a rare case of D-dependent rickets (VDDR) who presented with rachitic features but normal total 25-hydroxyvitamin 25(OH)D level. Conventional inactive supplementation was ineffective high dose ...

Hereditary hypophosphatemic rickets (HHR) are a group of diseases characterized by renal phosphate wasting causing growth retardation, rickets and osteomalacia. The most common form is the X-linked dominant hypophosphatemic rickets caused by inactivating mutations in the PHEX gene. The other hereditary hypophosphatemic syndromes present a lower prevalence. These include autosomal dominant hypop...