Purpose. To assess the conjunctival functionality in a rabbit dry eye (DE) model. Methods. Nictitating membrane, lacrimal and Harderian glands were surgically excised from male New Zealand white rabbits using minimally invasive surgery. Fluorescein/rose Bengal staining of ocular surface (OS) and Schirmer test were done before (BE) and after excision (AE). The expression of interleukin- (IL-) 1β...

PURPOSE Ocular side effects in patients using eye drops may be due to intolerance to the vector used in eye drops. Castor oil is the commonly used lipophilic vector but has been shown to be cytotoxic. Effects on cells of four oils (olive, camelina, Aleurites moluccana, maize) were compared with those of castor oil in human conjunctival cells. METHODS Human conjunctival cells were incubated wi...

PURPOSE With use of the Wong-Kilbourne derivative Chang conjunctival cell line, this study compared in vitro the ocular toxicity of three topical intraocular pressure (IOP)-lowering agents: travoprost 0.004% containing 0.015% benzalkonium chloride (BAK), travoprost Z 0.004%, a new formulation without BAK, and latanoprost 0.005% containing 0.02% BAK. METHODS Neutral red, Alamar blue, YOPRO-1, ...

AIM Investigate the efficiency of limbal conjunctival autograft in primary and recurrent pterygium. (2) To report the incidence of recurrence after primary and recurrent pterygium surgery using limbal conjunctival autograft. MATERIAL AND METHODS It is a prospective study conducted at Department of Ophthalmology, Basaveshwar Teaching and General Hospital, Gulbarga Karnataka, India for a period...

Background/Objective: Hyperphosphatemia is the consequence of end stage renal failure. Inadequate control of serum phosphorus results in elevated Ca×P product with subsequent soft tissue deposition in the form of conjunctival and corneal calcification.  In this study, we evaluated the relationship of conjunctival and corneal calcification with secondary hyperparathyroidism in hemodialysis patie...

PURPOSE To investigate the effect of inflammatory cytokines on the activity of the human MUC5AC promoter in vitro and in vivo. METHODS Conjunctival epithelial cells transfected with MUC5AC-luciferase plasmids challenged with different cytokines (tumor necrosis factor-alpha [TNF-alpha], interleukin [IL]-1beta, IL-2, IL-6, and IL-8) at various concentration (1, 10, 20, 50, 100, 200, 500, 1000, ...

purpose: to investigate the efficacy of limbal-conjunctival autografting technique in patients with primary pterygium methods: fifteen eyes of 15 patients with primary pterygium underwent surgery for the removal of pterygium with limbal-conjunctival autograft. after the pterygium excision, the limbal portion of the graft was oriented and sutured to the limbus at the recipient bed with the epith...

PURPOSE To determine the ocular anti-allergic effects of mapracorat, a novel selective glucocorticoid receptor agonist (SEGRA) in primary human conjunctival fibroblasts and epithelial cells. METHODS Two primary human conjunctival cell types, human conjunctival epithelial cells (HConEpiC) and human conjunctival fibroblasts (HConF), were challenged with interleukin-4 (IL-4) or IL-13 plus tumor ...

PURPOSE. Trachoma, the leading infectious cause of blindness, is a chronic inflammatory scarring condition. Blindness follows the development of trichiasis, which is treated surgically. Unfortunately, it frequently recurs, compromising the treatment. In this study, gene expression analysis was used to examine factors that may be involved in the inflammation and tissue remodeling after surgery. ...

OBJECTIVE To describe the ocular manifestations of Stevens-Johnson Syndrome/Toxic Epidermal Necrosis among inpatients at a tertiary care hospital. METHODS The retrospective observational descriptive study was carried out at the Aga Khan University Hospital, Karachi, and comprised data on age, gender, aetiology and ocular findings related to patients diagnosed with Stevens-Johnson Syndrome/Tox...